H3B-120
- Product Name
- H3B-120
- CAS No.
- 2194903-42-7
- Chemical Name
- H3B-120
- Synonyms
- H3B-120;H3B-120 ，S3244;H3B-120, 10 mM in DMSO;N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide;1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-;H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- CBNumber
- CB56193507
- Molecular Formula
- C19H24N4O2S
- Formula Weight
- 372.48
- MOL File
- 2194903-42-7.mol
H3B-120 Property
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (167.79 mM)
- pka
- 8.28±0.70(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChI
- 1S/C19H24N4O2S/c1-14-13-26-18(20-14)21-17(24)16-8-10-23(11-9-16)19(25)22(2)12-15-6-4-3-5-7-15/h3-7,13,16H,8-12H2,1-2H3,(H,20,21,24)
- InChIKey
- ZEVOZXRSCSSPAO-UHFFFAOYSA-N
- SMILES
- O=C(C1CCN(CC1)C(N(C)CC2=CC=CC=C2)=O)NC3=NC(C)=CS3
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SML3007
- Product name
- H3B-120
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $104
- Updated
- 2026/03/19
- Product number
- SML3007
- Product name
- H3B-120
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $420
- Updated
- 2026/03/19
- Product number
- CS-0119659
- Product name
- H3B-120
- Purity
- 98.45%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0119659
- Product name
- H3B-120
- Purity
- 98.45%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0119659
- Product name
- H3B-120
- Purity
- 98.45%
- Packaging
- 50mg
- Price
- $1350
- Updated
- 2021/12/16
H3B-120 Chemical Properties,Usage,Production
Uses
H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].
Biological Activity
H3B-120 is a competitive and selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits antitumor activity.
in vitro
H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
It achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
Also H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.
target
| Target | Value |
| CPS1 (Cell-free assay) | 1.4 μM(Ki) |
| CPS1 (Cell-free assay) | 1.5 μM |