ChemicalBook > CAS DataBase List > LQZ-7I

LQZ-7I

Product Name
LQZ-7I
CAS No.
195822-23-2
Chemical Name
LQZ-7I
Synonyms
LQZ-7I;LQZ-7I, 10 mM in DMSO;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
CBNumber
CB56193512
Molecular Formula
C20H14F2N4
Formula Weight
348.35
MOL File
195822-23-2.mol
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LQZ-7I Property

Melting point:
203 °C(Solv: ethanol (64-17-5))
Boiling point:
470.3±45.0 °C(Predicted)
Density 
1.390±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO: 125 mg/mL (358.83 mM)
form 
A solid
pka
2.56±0.59(Predicted)
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ambeed
Product number
A1275711
Product name
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity
98+%
Packaging
1mg
Price
$58
Updated
2021/12/16
Arctom
Product number
AS711703
Product name
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2021/12/16
Ambeed
Product number
A1275711
Product name
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity
98+%
Packaging
5mg
Price
$90
Updated
2021/12/16
Arctom
Product number
AS711703
Product name
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2021/12/16
Ambeed
Product number
A1275711
Product name
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity
98+%
Packaging
10mg
Price
$140
Updated
2021/12/16
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LQZ-7I Chemical Properties,Usage,Production

Biological Activity

LQZ-7I is an inhibitor targeting survivin. It can inhibits survivin dimerization and xenograft tumor growth and induces loss of survivin in the tumor.

in vitro

LQZ-7I has improved cytotoxicity with IC 50 s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin .

Western Blot Analysis

< tr>
Cell Line: PC- 3 or C4-2 cells
Concentration: 10 μM
Incubation Time: 0-6 hours
Result: Reduced the expression of survivin.

in vivo

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.

td>
Animal Model: 6-week old male NSG mice
Dosage: 100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO)
Administration: Oral gavage every other day for a total of ten treatments
Result: Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.

target

Survivin

LQZ-7I Preparation Products And Raw materials

Raw materials

Preparation Products

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LQZ-7I Suppliers

China 31 United States 6 Global 37
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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021-65675885 18964387627
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17754423994 17754423994
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2853530910@QQ.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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021-2022843681 15618226720
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lucy@atkchemical.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Bide Pharmatech Ltd.
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Sangon Biotech (Shanghai) Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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195822-23-2, LQZ-7IRelated Search:


  • LQZ-7I
  • 2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-
  • N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
  • LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
  • LQZ-7I, 10 mM in DMSO
  • 195822-23-2