ChemicalBook > CAS DataBase List > LQZ-7I

LQZ-7I

Product Name: LQZ-7I
CAS No.: 195822-23-2
Chemical Name: LQZ-7I
Synonyms: LQZ-7I;LQZ-7I, 10 mM in DMSO;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
CBNumber: CB56193512
Molecular Formula: C20H14F2N4
Formula Weight: 348.35
MOL File: 195822-23-2.mol

Less

LQZ-7I Property

Melting point:: 203 °C(Solv: ethanol (64-17-5))
Boiling point:: 470.3±45.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO: 125 mg/mL (358.83 mM)
form: A solid
pka: 2.56±0.59(Predicted)
color: Light yellow to green yellow

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Ambeed

Product number: A1275711
Product name: N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity: 98+%
Packaging: 1mg
Price: $58
Updated: 2021/12/16

Arctom

Product number: AS711703
Product name: N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2021/12/16

Ambeed

Product number: A1275711
Product name: N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity: 98+%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

Arctom

Product number: AS711703
Product name: N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2021/12/16

Ambeed

Product number: A1275711
Product name: N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
Purity: 98+%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

Less

LQZ-7I Chemical Properties,Usage,Production

Uses

LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors[1].

Biological Activity

LQZ-7I is an inhibitor targeting survivin. It can inhibits survivin dimerization and xenograft tumor growth and induces loss of survivin in the tumor.

in vitro

LQZ-7I has improved cytotoxicity with IC ₅₀ s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin .

Western Blot Analysis

< tr>

Cell Line:	PC- 3 or C4-2 cells
Concentration:	10 μM
Incubation Time:	0-6 hours
Result:	Reduced the expression of survivin.

in vivo

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.

td>

Animal Model:	6-week old male NSG mice
Dosage:	100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO)
Administration:	Oral gavage every other day for a total of ten treatments
Result:	Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.

target

Survivin

References

[1] Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9. DOI:10.1021/acs.jmedchem.0c00475

LQZ-7I Preparation Products And Raw materials

Raw materials

Preparation Products

Less

LQZ-7I Suppliers

China 35 United States 6 Global 41

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1984
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10151
Advantage: 58

Shaoguan Qicheng Biotechnology Co., Ltd

Tel: 18122215013
Email: 780229652@qq.com
Country: China
ProdList: 1292
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Country: China
ProdList: 8510
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Guangzhou Haotian Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 122
Advantage: 58

Guangzhou Yiran Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 141
Advantage: 58

Guangzhou Baide Biotechnology Co., Ltd.

Tel: 18925065404
Country: CHINA
ProdList: 168
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

195822-23-2, LQZ-7IRelated Search:

LQZ-7I

2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-

N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine

LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization

LQZ-7I, 10 mM in DMSO

195822-23-2