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(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID

Product Name
(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID
CAS No.
38107-10-7
Chemical Name
(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID
Synonyms
RARECHEM AL BO 0890;4-Phenyl-2-thiazoleacetic acid;4-phenylthiazole-2-ylacetic acid;2-Thiazoleacetic acid, 4-phenyl-;2-(4-phenylthiazol-2-yl)acetic acid;(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID;(4-Phenyl-1,3-thiazol-2-yl)acetic acid;2-(4-phenyl-1,3-thiazol-2-yl)acetic Acid
CBNumber
CB5670707
Molecular Formula
C11H9NO2S
Formula Weight
219.26
MOL File
38107-10-7.mol
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(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID Property

Melting point:
90-91℃
Density 
1.329
storage temp. 
2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P336955
Product name
4-Phenyl-2-thiazoleaceticAcid
Packaging
500mg
Price
$165
Updated
2021/12/16
TRC
Product number
P336955
Product name
4-Phenyl-2-thiazoleaceticAcid
Packaging
5g
Price
$1320
Updated
2021/12/16
Matrix Scientific
Product number
082586
Product name
(4-Phenyl-1,3-thiazol-2-yl)acetic acid
Purity
97%
Packaging
1g
Price
$524
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0162021
Product name
(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID
Purity
95.00%
Packaging
1G
Price
$629.53
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48288
Product name
4-Phenyl-2-thiazoleaceticAcid
Packaging
500mg
Price
$650
Updated
2021/12/16
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(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID Chemical Properties,Usage,Production

Uses

4-Phenyl-2-thiazoleacetic Acid is a reactant used to prepare heterocyclic acetamide and benzamide derivatives as β3-adrenergic receptor agonists.

Synthesis

41381-89-9

38107-10-7

General procedure for the synthesis of 4-phenyl-2-thiazoleacetic acid from 2-(4-phenylthiazol-2-yl)acetonitrile: To a solution of 2-(4-phenylthiazol-2-yl)acetonitrile (130 mg, 0.649 mmol) in ethanol (1.5 mL) was added a 5 M sodium hydroxide solution (0.389 mL, 1.947 mmol). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the reaction solution was diluted with 1 M aqueous hydrochloric acid solution (5 mL) and subsequently extracted five times with chloroform (10 mL). The organic layers were combined and dried with magnesium sulfate. The solvent was removed by evaporation under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio chloroform:methanol:acetic acid = 10:1:0.1) to afford 4-phenyl-2-thiazoleacetic acid (77.2 mg, 54% yield) as a brown oil.1H-NMR (DMSO-d6) data were as follows: δ (ppm) 4.13 (s, 2H), 7.30-7.37 (m, 1H). 7.39-7.47 (m, 2H), 7.90-7.97 (m, 2H), 8.04 (s, 1H), 12.81 (brs, 1H).

References

[1] Patent: EP2351744, 2011, A1. Location in patent: Page/Page column 60

(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID Suppliers

China 45 Germany 1 India 1 United Kingdom 2 United States 8 Global 57
Shanghai Ennopharm Co., Ltd.
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+86 (21) 6435-5022
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China
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Jinan Mingya Medical Technology Co., Ltd.
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0531-85828981
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+86-531-85806006
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864598798@qq.com
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China
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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021-61478794
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sales@hcshhai.com
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China
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021- 64345308
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Shanghai Kahn Pharmaceutical Co., Ltd.
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Shanghai Carlow Chemicals Co., Ltd.
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+86 21 37023730
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info@carlowchem.com
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Changzhou Hopschain Chemical Co.,Ltd.
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0519-85528066 13775048983
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0519-85528066
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sales@hopschem.com
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China
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Grader reagent
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18221735425
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sales@xinpingchem.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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View Lastest Price from (4-PHENYL-THIAZOL-2-YL)-ACETIC ACID manufacturers

Career Henan Chemical Co
Product
(4-PHENYL-THIAZOL-2-YL)-ACETIC ACID 38107-10-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-03-23

38107-10-7, (4-PHENYL-THIAZOL-2-YL)-ACETIC ACIDRelated Search:

Brofezil (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID ETHYL ESTER (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID [2-(3,4-DIMETHOXY-PHENYL)-THIAZOL-4-YL]-ACETIC ACID [2-(4-HYDROXY-PHENYL)-THIAZOL-4-YL]-ACETIC ACID [2-AMINO-4-(4-ETHYL-PHENYL)-THIAZOL-5-YL]-ACETIC ACID [2-(4-CHLORO-PHENYL)-4-PHENYL-THIAZOL-5-YL]-ACETIC ACID [2-(2-FLUORO-PHENYL)-THIAZOL-4-YL]-ACETIC ACID 2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetic acid 2-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetic acid (2-METHYL-4-PHENYL-THIAZOL-5-YL)-ACETIC ACID [2-AMINO-4-(4-ETHYL-PHENYL)-THIAZOL-5-YL]-ACETIC ACID HYDROCHLORIDE (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID HYDROCHLORIDE [2-(3,4-DIMETHOXY-PHENYL)-THIAZOL-4-YL]-ACETIC ACID ETHYL ESTER 2-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]acetic acid 2-[4-(4-fluorophenyl)-5-methyl-1,3-thiazol-2-yl]acetic acid 2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]acetic acid 2-[4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2-yl]acetic acid

  • (4-PHENYL-THIAZOL-2-YL)-ACETIC ACID
  • RARECHEM AL BO 0890
  • 2-(4-phenylthiazol-2-yl)acetic acid
  • (4-Phenyl-1,3-thiazol-2-yl)acetic acid
  • 4-phenylthiazole-2-ylacetic acid
  • 4-Phenyl-2-thiazoleacetic acid
  • 2-(4-phenyl-1,3-thiazol-2-yl)acetic Acid
  • 2-Thiazoleacetic acid, 4-phenyl-
  • 38107-10-7