Physalaemin

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Product Name: Physalaemin
CAS No.: 2507-24-6
Chemical Name: Physalaemin
Synonyms: FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
CBNumber: CB5674482
Molecular Formula: C58H84N14O16S
Formula Weight: 1265.44
MOL File: 2507-24-6.mol

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Physalaemin Property

storage temp.: −20°C
solubility: Soluble in DMSO
InChI: InChI=1/C58H84N14O16S/c1-31(2)25-39(54(84)66-36(49(61)79)21-24-89-4)65-47(76)30-62-51(81)40(27-34-15-17-35(73)18-16-34)68-55(85)41(26-33-11-6-5-7-12-33)69-53(83)37(13-8-9-22-59)67-56(86)42(28-45(60)74)70-57(87)44-14-10-23-72(44)58(88)43(29-48(77)78)71-50(80)32(3)63-52(82)38-19-20-46(75)64-38/h5-7,11-12,15-18,31-32,36-44,73H,8-10,13-14,19-30,59H2,1-4H3,(H2,60,74)(H2,61,79)(H,62,81)(H,63,82)(H,64,75)(H,65,76)(H,66,84)(H,67,86)(H,68,85)(H,69,83)(H,70,87)(H,71,80)(H,77,78)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-/s3
InChIKey: SHSUJLMLURFKID-PYQGFWJGNA-N
SMILES: [C@@H]1(C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N)CCSC)CC2C=CC(O)=CC=2)CC2C=CC=CC=2)CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1 |&1:0,4,12,21,25,33,41,70,78,83,r|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: P4079-40
Product name: Physalaemin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002856
Product name: PHYSALAEMIN
Purity: 95.00%
Packaging: 1MG
Price: $571.21
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002856
Product name: PHYSALAEMIN
Purity: 95.00%
Packaging: 5MG
Price: $679.72
Updated: 2021/12/16

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Physalaemin Chemical Properties,Usage,Production

Description

Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

Uses

Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

Biological Activity

Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.

in vitro

Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).

target

Neurokinin-1 (NK1) receptor

References

[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

Physalaemin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Physalaemin manufacturers

Career Henan Chemical Co

Product: PHYSALAEMIN 2507-24-6
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

2507-24-6, PhysalaeminRelated Search:

[L-Lys5,L-Thr6]physalaemin physalaemin, Lys(5)-Thr(6)- physalaemin C-terminal heptapeptide [[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11) GLY-LEU-MET-NH2 4-PYRROLIDIN-1-YL-BUTAN-1-OL AC-PHE-TYR-NH2 SUBSTANCE P (7-11) Physalaemin N,N-DIMETHYLSUCCINAMIC ACID 4-OXO-4-PYRROLIDIN-1-YL-BUTYRIC ACID AC-MET-NH2 pyrrolidine-1-butyric acid 4-(2-CARBAMOYL-PYRROLIDIN-1-YL)-4-OXO-BUTYRIC ACID

FI 6422

Physalemin(7CI,8CI,9CI)

PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2

PHYSALAEMIN

PHYSALAEMIN ACOH 3H2O

PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2

PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2

PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O

GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2

5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2

L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2

Physalaemine

Physalemin

Physalaemin, ≥97% (HPLC)

L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-

2507-24-6

C58H84N14O16S1

C58H84N14O16S

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

Tachykinins

Peptide