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Physalaemin

Product Name
Physalaemin
CAS No.
2507-24-6
Chemical Name
Physalaemin
Synonyms
FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
CBNumber
CB5674482
Molecular Formula
C58H84N14O16S
Formula Weight
1265.44
MOL File
2507-24-6.mol
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Physalaemin Property

storage temp. 
−20°C
solubility 
Soluble in DMSO
InChI
InChI=1/C58H84N14O16S/c1-31(2)25-39(54(84)66-36(49(61)79)21-24-89-4)65-47(76)30-62-51(81)40(27-34-15-17-35(73)18-16-34)68-55(85)41(26-33-11-6-5-7-12-33)69-53(83)37(13-8-9-22-59)67-56(86)42(28-45(60)74)70-57(87)44-14-10-23-72(44)58(88)43(29-48(77)78)71-50(80)32(3)63-52(82)38-19-20-46(75)64-38/h5-7,11-12,15-18,31-32,36-44,73H,8-10,13-14,19-30,59H2,1-4H3,(H2,60,74)(H2,61,79)(H,62,81)(H,63,82)(H,64,75)(H,65,76)(H,66,84)(H,67,86)(H,68,85)(H,69,83)(H,70,87)(H,71,80)(H,77,78)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-/s3
InChIKey
SHSUJLMLURFKID-PYQGFWJGNA-N
SMILES
[C@@H]1(C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N)CCSC)CC2C=CC(O)=CC=2)CC2C=CC=CC=2)CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1 |&1:0,4,12,21,25,33,41,70,78,83,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
P4079-40
Product name
Physalaemin
Packaging
1mg
Price
$531
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0002856
Product name
PHYSALAEMIN
Purity
95.00%
Packaging
1MG
Price
$571.21
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0002856
Product name
PHYSALAEMIN
Purity
95.00%
Packaging
5MG
Price
$679.72
Updated
2021/12/16
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Physalaemin Chemical Properties,Usage,Production

Description

Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

Uses

Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

Biological Activity

Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.

in vitro

Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).

target

Neurokinin-1 (NK1) receptor

References

[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

Physalaemin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Physalaemin manufacturers

Career Henan Chemical Co
Product
PHYSALAEMIN 2507-24-6
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

2507-24-6, PhysalaeminRelated Search:


  • FI 6422
  • Physalemin(7CI,8CI,9CI)
  • PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • PHYSALAEMIN
  • PHYSALAEMIN ACOH 3H2O
  • PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2
  • PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O
  • GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • 5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
  • L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
  • Physalaemine
  • Physalemin
  • Physalaemin, ≥97% (HPLC)
  • L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-
  • 2507-24-6
  • C58H84N14O16S1
  • C58H84N14O16S
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • Peptides
  • Tachykinins
  • Peptide