13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2

Product Name: 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2
CAS No.: 59894-07-4
Chemical Name: 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2
Synonyms: DK-PGD2;13,14-Dihydro-15-keto-PGD2;13,14-dihydro-15-keto Prostaglandin D;13,14-Dihydro-15-ketoprostadlandin D2;13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2;13,14-dihydro-15-keto Prostaglandin D₂;9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID;(5Z,9α)-9-Hydroxy-11,15-dioxoprost-5-en-1-oic acid;13,14-dihydro-15-keto Prostaglandin D2 MaxSpecStandard;Prost-5-en-1-oic acid, 9-hydroxy-11,15-dioxo-, (5Z,9α)-
CBNumber: CB5674543
Molecular Formula: C20H32O5
Formula Weight: 352.47
MOL File: 59894-07-4.mol

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13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Property

Boiling point:: 542.1±40.0 °C(Predicted)
Density: 1.086±0.06 g/cm3(Predicted)
solubility: DMF: 50 mg/ml
DMSO: 30 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 2.5 mg/ml
pka: 4.76±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 12610
Product name: 13,14-dihydro-15-keto Prostaglandin D2
Purity: ≥95%
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 12610
Product name: 13,14-dihydro-15-keto Prostaglandin D2
Purity: ≥95%
Packaging: 5mg
Price: $576
Updated: 2024/03/01

Cayman Chemical

Product number: 12610
Product name: 13,14-dihydro-15-keto Prostaglandin D2
Purity: ≥95%
Packaging: 10mg
Price: $1019
Updated: 2024/03/01

Cayman Chemical

Product number: 10007208
Product name: 13,14-dihydro-15-keto Prostaglandin D2 MaxSpec? Standard
Purity: >95%
Packaging: 100μg
Price: $185
Updated: 2023/06/20

TRC

Product number: D447790
Product name: 13,14-Dihydro-15-keto-PGD2
Packaging: 1mg
Price: $440
Updated: 2021/12/16

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13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Chemical Properties,Usage,Production

Description

13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH2/DP₂ receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.

Uses

13,14-Dihydro-15-keto-PGD2 is a metabolite of Prostaglandin D2 (CAT# P838575) and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases.

Definition

ChEBI: 13,14-dihydro-15-ketoprostaglandin D2 is a prostaglandins D. It has a role as a metabolite. It is functionally related to a prostaglandin D2.

References

[1] P K RANGACHARI P A B. Biological activity of metabolites of PGD2 on canine proximal colon.[J]. American Journal of Physiology, 1993, 264 5 Pt 1: G886-94. DOI: 10.1152/ajpgi.1993.264.5.g886
[2] H. HIRAI. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2[J]. The Tokushima journal of experimental medicine, 2001, 1 1: 255-262. DOI: 10.1084/jem.193.2.255
[3] T E LISTON L J R. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.[J]. The Journal of Biological Chemistry, 1985, 260 24: 13172-13180.
[4] JASON D. MORROW. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay[J]. Analytical biochemistry, 1991, 193 1: Pages 142-148. DOI: 10.1016/0003-2697(91)90054-w
[5] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700
[6] VICTORIA GÓMEZ-ABELLÁN . Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish[J]. Developmental and comparative immunology, 2015, 52 2: Pages 182-191. DOI: 10.1016/j.dci.2015.04.017
[7] RALF SCHRÖDER. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.[J]. PLoS ONE, 2012: e33329. DOI: 10.1371/journal.pone.0033329

13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Preparation Products And Raw materials

Raw materials

Preparation Products

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13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Suppliers

China 17 United Kingdom 1 United States 4 Global 22

Shanghai Boyle Chemical Co., Ltd.

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59894-07-4, 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2Related Search:

ALLYLCYCLOPENTANE CIS-5-DODECENOIC ACID cis-5-Eicosenoic acid 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2

13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2

9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID

(5Z,9α)-9-Hydroxy-11,15-dioxoprost-5-en-1-oic acid

13,14-Dihydro-15-keto-PGD2

13,14-Dihydro-15-ketoprostadlandin D2

DK-PGD2

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13,14-dihydro-15-keto Prostaglandin D<sub>2</sub>

13,14-dihydro-15-keto Prostaglandin D2 MaxSpecStandard

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13,14-dihydro-15-keto Prostaglandin D

59894-07-4