ChemicalBook > CAS DataBase List > ICI-118,551

ICI-118,551

Product Name
ICI-118,551
CAS No.
72795-19-8
Chemical Name
ICI-118,551
Synonyms
Ici 111,581;ICI-118,551;ICI118551HCl;ICI 118,551 HYDROCHLORIDE;ICI 118551 Hydrochloride ((±ICI-118-551 HYDROCHLORIDE HIGHLY SELECTI VE B2 A;Erythro-DL-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol;erythro-DL-1-(7-Methylindan-4-yloxy)-3-isopropylamino-2-butanol;(2R,3S)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol;2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (2R,3S)-rel-
CBNumber
CB5676244
Molecular Formula
C17H27NO2
Formula Weight
277.4
MOL File
72795-19-8.mol
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ICI-118,551 Property

Melting point:
217-219°C
Boiling point:
439.3±45.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
ethanol: 7.3 mg/mL
form 
powder
pka
13.87±0.20(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05275
Product name
ICI 118551 Hydrochloride - CAS 72795-19-8 - Calbiochem
Packaging
10mg
Price
$272
Updated
2025/07/31
Tocris
Product number
0821
Product name
ICI 118,551 hydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$198
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000337
Product name
ICI-118551
Purity
95.00%
Packaging
5MG
Price
$540
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000337
Product name
ICI-118551
Purity
95.00%
Packaging
10MG
Price
$575
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0000019
Product name
ICI 118,551 HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$702.19
Updated
2021/12/16
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ICI-118,551 Chemical Properties,Usage,Production

Uses

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

Definition

ChEBI: ICI 118551 is an indane substituted at position 7 by a methyl group and at position 4 by a 3-(isopropylamino)-2-hydroxybutoxy group (the 2R,3S-diastereomer). It has a role as a beta-adrenergic antagonist. It is a member of indanes, an aromatic ether, a secondary alcohol and a secondary amino compound.

Biological Activity

Primary Target
-2 adrenergic receptors', 'Reversible: yes', 'Target Ki: 1.2, 120 and 257 nM for -2, -1 and -3 receptors respectively.

ICI-118,551 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICI-118,551 Suppliers

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72795-19-8, ICI-118,551Related Search:

3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 2-Aminoimidazole hemisulfate 4-HYDROXY-7-METHYLINDANE toliprolol 3-O-TOLYLOXY-PROPYLAMINE (S)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL METHYL-(3-O-TOLYLOXY-PROPYL)-AMINE 4-METHOXY-7-METHYLINDANE AKOS BC-1949 AKOS BC-1943 3-(3-METHYLPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE 1-AMINO-3-(2,4-DIMETHYL-PHENOXY)-PROPAN-2-OL Dihydroalprenolol ICI-118,551 (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL AKOS BBS-00007965 CHEMBRDG-BB 9070438 AKOS BC-1937

  • 2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (2R,3S)-rel-
  • 2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (R*,S*)-(+-)-
  • Erythro-DL-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol
  • Ici 111,581
  • (2R,3S)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol
  • (+/-)-1-[2,3-(DIHYDRO-7-METHYL-1H-INDEN-4-YL)OXY]-3-[(1-METHYLETHYL)AMINO]-2-BUTANOL HYDROCHLORIDE
  • ICI-118-551 HYDROCHLORIDE HIGHLY SELECTI VE B2 A
  • ICI118551HCl
  • ICI-118,551
  • ICI 118,551 HYDROCHLORIDE
  • ICI 118551 Hydrochloride ((&plusmn
  • erythro-DL-1-(7-Methylindan-4-yloxy)-3-isopropylamino-2-butanol
  • 72795-19-8
  • C17H28NO2Cl