ChemicalBook > CAS DataBase List > (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

Product Name: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE
CAS No.: 169274-78-6
Chemical Name: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE
Synonyms: CS-2705;RO 25-6981 MALEATE;Ro 25-6981 free base;Ro 256981,Ro 25 6981;Ro 25-6981 maleate salt;Ro 25-6981, 10 mM in DMSO;(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol;1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, (αR,βS)-;(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate;(aR,bS)-a-(4-Hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
CBNumber: CB5676648
Molecular Formula: C22H29NO2
Formula Weight: 339.47
MOL File: 169274-78-6.mol

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(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Property

Boiling point:: 512.4±45.0 °C(Predicted)
Density: 1.116±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: DMSO : 100 mg/mL (294.58 mM; Need ultrasonic)
form: Powder
pka: 10.01±0.26(Predicted)
color: White to off-white
Water Solubility: H2O: 25mM

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04845
Product name: Ro 25-6981 Maleate Salt - CAS 169274-78-6 - Calbiochem
Packaging: 1MG
Price: $94.3
Updated: 2023/01/07

Tocris

Product number: 1594
Product name: Ro25-6981maleate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $182
Updated: 2021/12/16

Tocris

Product number: 1594
Product name: Ro25-6981maleate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $756
Updated: 2021/12/16

Tocris

Product number: 1594
Product name: Ro25-6981maleate
Purity: ≥98%(HPLC)
Packaging: 1
Price: $86
Updated: 2021/12/16

ChemScene

Product number: CS-2011
Product name: Ro25-6981
Packaging: 100mg
Price: $900
Updated: 2021/12/16

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(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Chemical Properties,Usage,Production

Uses

Ro 25-6981 maleate is a potent NMDA receptor antagonist.

Definition

ChEBI: Ro 25-6981 is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor. It has a role as a NMDA receptor antagonist, an anticonvulsant, an antidepressant and a neuroprotective agent. It is a member of piperidines, a member of phenols, a secondary alcohol, a tertiary amino compound and a member of benzenes. It is a conjugate base of a Ro 25-6981(1+).

Biological Activity

Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC 50 values are 0.009 and 52 μ M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro .

in vivo

Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats^[1].
Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats^[2].
Ro 25-6981 (800 μg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia^[3].

Animal Model:	6-OHDA-lesioned rats^[1]
Dosage:	0.39-12.5 mg/kg
Administration:	I.p.
Result:	Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound.

Animal Model:	Male albino rats of Wistar strain^[2]
Dosage:	1, 3 mg/kg
Administration:	I.p.
Result:	Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.

IC 50

NMDA Receptor

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE manufacturers

Career Henan Chemical Co

Product: (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE 169274-78-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

169274-78-6, (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATERelated Search:

1-Piperidinepropanol (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

RO 25-6981 MALEATE

(alpha-R,beta-S)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate

Ro 25-6981 maleate salt

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate

(aR,bS)-a-(4-Hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate

(alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol

CS-2705

(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol

1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, (αR,βS)-

Ro 25-6981 free base

(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate

Ro 256981,Ro 25 6981

Ro 25-6981, 10 mM in DMSO

169274-78-6

C22H29NO2C4H4O4

Glutamate

API