4-HYDROXY-6-METHYLQUINOLINE
- Product Name
- 4-HYDROXY-6-METHYLQUINOLINE
- CAS No.
- 23432-40-8
- Chemical Name
- 4-HYDROXY-6-METHYLQUINOLINE
- Synonyms
- Nsc82351;6-Methyl-4-quinolinol;6-METHYL-QUINOLIN-4-OL;4-Quinolinol, 6-methyl-;6-METHYL-4(1H)-QUINOLINONE;4-HYDROXY-6-METHYLQUINOLINE;6-methyl-4-quinolinol(SALTDATA: FREE);6-Methyl-4(1H)-quinolinone([97545-52-3])
- CBNumber
- CB5679043
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 23432-40-8.mol
4-HYDROXY-6-METHYLQUINOLINE Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Off-white to light brown Solid
N-Bromosuccinimide Price
- Product number
- BBO000008
- Product name
- 4-Hydroxy-6-methylquinoline
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- M321560
- Product name
- 6-Methylquinolin-4-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M321560
- Product name
- 6-Methylquinolin-4-ol
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-1-526
- Product name
- 4-Hydroxy-6-methylquinoline
- Packaging
- 1g
- Price
- $208
- Updated
- 2021/12/16
- Product number
- 4H56-1-526
- Product name
- 4-Hydroxy-6-methylquinoline
- Packaging
- 5G
- Price
- $512
- Updated
- 2021/12/16
4-HYDROXY-6-METHYLQUINOLINE Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 2772, 1984 DOI: 10.1021/jo00189a025
Synthesis
25428-06-2
109-94-4
23432-40-8
Example 4: Synthesis of 6-methyl-4-quinolone 1. In a dry reaction flask, 2-amino-5-methylacetophenone (99 mg, 0.67 mmol) was dissolved in toluene (8 mol) to form a homogeneous solution. 2. To the above solution, sodium hydride (60% oil dispersion, 80 mg, 2 mmol) was slowly added and the reaction mixture was stirred at room temperature for 30 min. 3. Ethyl formate (0.27 ml, 3.3 mmol) was added dropwise, and after addition, the reaction mixture was continued to be stirred at room temperature overnight. 4. After completion of the reaction, water (3 ml) was slowly added to the reaction solution and stirred for 5 minutes. 5. The reaction solution was adjusted to neutral with 10% hydrochloric acid solution and crystals were precipitated. 6. 6. The precipitated crystals were collected by filtration, washed with cold water (3 ml x 2) and dried to give 6-methyl-4-quinolone (56 mg, 53% yield). Product Characterization: 1H-NMR (DMSO-d6, 400MHz): δ 2.40 (s, 3H), 5.99 (dd, J = 1.2, 7.3Hz, 1H), 7.41-7.49 (m, 2H), 7.84 (dd, J = 5.9, 7.3Hz, 1H), 7.87 (s, 1H), 11.7 (brs, 1H). Mass spectrum (FD-MS, m/z): 159 (M+).
References
[1] Patent: US6187926, 2001, B1
4-HYDROXY-6-METHYLQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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