4-FLUORO-3-IODOBENZOIC ACID
- Product Name
- 4-FLUORO-3-IODOBENZOIC ACID
- CAS No.
- 403-18-9
- Chemical Name
- 4-FLUORO-3-IODOBENZOIC ACID
- Synonyms
- BUTTPARK 122\01-04;4-FLUORO-3-IODOBENZOIC ACID;3-Iodo-4-fluorobenzoic acid;Benzoic acid, 4-fluoro-3-iodo-
- CBNumber
- CB5688135
- Molecular Formula
- C7H4FIO2
- Formula Weight
- 266.01
- MOL File
- 403-18-9.mol
4-FLUORO-3-IODOBENZOIC ACID Property
- Melting point:
- 176.6-177
- Boiling point:
- 339℃
- Density
- 2.074
- Flash point:
- 159℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.79±0.10(Predicted)
- form
- powder
- color
- White
- Sensitive
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F592008
- Product name
- 4-Fluoro-3-iodobenzoicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC9217
- Product name
- 4-Fluoro-3-iodobenzoicacid
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- 2621-K-04
- Product name
- 4-Fluoro-3-iodobenzoic acid
- Packaging
- 5G
- Price
- $128
- Updated
- 2021/12/16
- Product number
- PC9217
- Product name
- 4-Fluoro-3-iodobenzoicacid
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 074233
- Product name
- 4-Fluoro-3-iodobenzoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
4-FLUORO-3-IODOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
light yellow powder
Synthesis
2365-85-7
403-18-9
The general procedure for the synthesis of 3-iodo-4-fluorobenzoic acid from 3-amino-4-fluorobenzoic acid is as follows: to a concentrated aqueous hydrochloric acid solution (37%, w/w, 8 mL) of 3-amino-4-fluorobenzoic acid (5) (1.00 g, 6.45 mmol) was added dropwise an aqueous (10 mL) solution of sodium nitrite (667 mg, 9.67 mmol) at -15 °C, while maintaining the reaction temperature below -10°C. After continued stirring at -10 °C for 30 min, a solution of potassium iodide (3.21 g, 19.34 mmol) in water (10 mL) was slowly added, keeping the temperature below -5 °C. The reaction mixture was gradually warmed to 0 °C and stirred for 30 min, followed by standing for 3 h at room temperature. Upon completion of the reaction, the pH was adjusted to 3 by slow addition of 10 N aqueous sodium hydroxide solution and then the reaction was quenched with 1 M aqueous sodium thiosulfate solution (20 mL) at 0 °C. The reaction mixture was extracted with dichloromethane (3 x 50 mL), the organic layers were combined and washed with deionized water (20 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 4-fluoro-3-iodobenzoic acid (6) (1.47 g, 5.53 mmol) as an orange solid in 86% yield. The product characterization data were as follows: melting point 169-171 °C (literature value [1]: 173-174 °C); IR (KBr) νmax 1039, 1291, 1426, 1484, 1585, 1686, 2500-3100 cm-1; 1H NMR (500 MHz, CDCl3) δ 7.16 (t, 1H, J = 7.8 Hz. 3JH-F = 7.8 Hz, H-5), 8.10 (m, 1H, H-6), 8.54 (dd, 1H, 4JH-F = 6.0 Hz, J = 2.1 Hz, H-2); 13C NMR (50 MHz, DMSO-d6) δ 83.0 (d, 2JC-F = 27 Hz, C-3), 116.5 (d, 2JC-F = 25 Hz, C-5), 129.5 (C-1), 132.4 (d, 3JC-F = 9 Hz, C-6), 140.9 (C-2), 164.5 (d, 1JC-F = 249 Hz, C-4), 165.7 (CO); 19F NMR (470 MHz, CDCl3) δ -86.0; ESI-MS m/z 264.94 [M-H]-.
References
[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 168 - 172
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
4-FLUORO-3-IODOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-3-IODOBENZOIC ACID manufacturers
- Product
- 4-Fluoro-3-iodobenzoic acid 403-18-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 4-Fluoro-3-iodobenzoic acid 403-18-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.2%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 4-Fluoro-3-iodobenzoic acid 403-18-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14