1-BROMO-3,3-DIMETHYLBUTANE

Product Name: 1-BROMO-3,3-DIMETHYLBUTANE
CAS No.: 1647-23-0
Chemical Name: 1-BROMO-3,3-DIMETHYLBUTANE
Synonyms: BrCH2CH2C(CH3)3;3-DIMETHYLBUTANE;1-Brom-3,3-dimethylbutan;3,3-dimethyl-1-bromobutane;1-BROMO-3,3-DIMETHYLBUTANE;1-Bromo-3,3-dimethlybutane;Butane,1-bromo-3,3-dimethyl-;Butane, 1-bromo-3,3-dimethyl-
CBNumber: CB5692606
Molecular Formula: C6H13Br
Formula Weight: 165.07
MOL File: 1647-23-0.mol

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1-BROMO-3,3-DIMETHYLBUTANE Property

Melting point:: -44.22°C (estimate)
Boiling point:: 147.26°C (estimate)
Density: 1.1497
refractive index: 1.4424
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Almost colorless
InChI: InChI=1S/C6H13Br/c1-6(2,3)4-5-7/h4-5H2,1-3H3
InChIKey: ROKZAMCDHKVZIQ-UHFFFAOYSA-N
SMILES: C(Br)CC(C)(C)C

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Safety

HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5948
Product name: 1-Bromo-3,3-dimethylbutane
Packaging: 5G
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: B5948
Product name: 1-Bromo-3,3-dimethylbutane
Packaging: 25G
Price: $252
Updated: 2025/07/31

TRC

Product number: B678398
Product name: 1-Bromo-3,3-dimethylbutane
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 240396
Product name: 1-Bromo-3,3-dimethylbutane
Packaging: 1g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB162530
Product name: 1-Bromo-3,3-dimethylbutane
Packaging: 2g
Price: $60
Updated: 2021/12/16

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1-BROMO-3,3-DIMETHYLBUTANE Chemical Properties,Usage,Production

Uses

1-Bromo-3,3-dimethylbutane is a useful reagent for the preparation of macrocycles as modulators of CFTR in the treatment of cystic fibrosis.

Synthesis

624-95-3

1647-23-0

General procedure for the synthesis of 3,3-dimethyl-1-butane from 3,3-dimethyl-1-butyrate: In a 1-liter round-bottomed flask fitted with a reflux condenser, the reaction mixture was cooled to 0°C in an ice bath, and 232 g of concentrated sulfuric acid and 283 g of hydrobromic acid (48% aqueous solution) were added sequentially. The mixture was refluxed for 6 h. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of 400 g of ice. The aqueous phase was extracted with 400 ml of pentane and the combined organic layers were washed sequentially with methanol, aqueous NaOH and water. The organic layer was dried with anhydrous magnesium sulfate, filtered and the solvent was removed in vacuum. The product was purified by vacuum distillation to afford 88.1 g (55% yield) of 1-bromo-3,3-dimethylbutane as a colorless oily liquid. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ = 3.35 (m, 2H, CH2Br), 1.80 (m, 2H, CH2), 0.90 (s, 9H, t-Bu) ppm.

References

[1] Bioorganic and Medicinal Chemistry, 2000, vol. 8, # 3, p. 665 - 674
[2] Journal of the American Chemical Society, 1992, vol. 114, # 5, p. 1778 - 1784
[3] Patent: US8299287, 2012, B2. Location in patent: Page/Page column 53
[4] Patent: JP6196581, 2017, B2. Location in patent: Paragraph 0186
[5] Chemische Berichte, 1983, vol. 116, # 4, p. 1345 - 1363

1-BROMO-3,3-DIMETHYLBUTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-3,3-DIMETHYLBUTANE Suppliers

Americas 1 China 71 Europe 1 India 3 Japan 1 Ukraine 1 United Kingdom 4 United States 8 Global 90

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View Lastest Price from 1-BROMO-3,3-DIMETHYLBUTANE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-BROMO-3,3-DIMETHYLBUTANE 1647-23-0
Price: US $80.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-27

Unipharm pharmaceutical industry Co., Ltd

Product: 1-Bromo-3,3-dimethylbutane 1647-23-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: EX: 100kgs
Release date: 2021-03-24

Career Henan Chemical Co

Product: 1-BROMO-3,3-DIMETHYLBUTANE 1647-23-0
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

1647-23-0, 1-BROMO-3,3-DIMETHYLBUTANERelated Search:

1,2-DIBROMO-3,3-DIMETHYLBUTANE D-3-BROMOCAMPHOR 1-Bromopinacolone (+)-Camphor Bromide S-(-)-3-Bromocamphor 1-BROMO-3,3-DIMETHYLBUTANE 4-BROMO-2,2-DIPHENYLBUTYRONITRILE 1,1-DIBROMOPINACOLONE 1-ADAMANTYL BROMOMETHYL KETONE 1-Bromo-3,5-dimethyladamantane 1-Bromobutane ETHYL DELTA-BROMO-BETA,BETA-DIMETHYL LEVULINATE, 96 16A-BROMOANDROSTERONE BORNYL BROMIDE 1,5-DIBROMO-3,3-DIMETHYLPENTANE [S,(+)]-1-Bromo-2,3-dimethylbutane 1-bromo-2,3-dimethylbutane 3-BROMO-7-(BROMOMETHYL)-1,7-DIMETHYLBICYCLO[2.2.1]HEPTAN-2-ONE

3,3-dimethyl-1-bromobutane

BrCH2CH2C(CH3)3

Butane, 1-bromo-3,3-dimethyl-

Butane,1-bromo-3,3-dimethyl-

1-Bromo-3,3-dimethlybutane

1-BROMO-3,3-DIMETHYLBUTANE

1-Brom-3,3-dimethylbutan

3-DIMETHYLBUTANE

1647-23-0

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