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1,1-DIPHENYLHYDRAZINE

Product Name
1,1-DIPHENYLHYDRAZINE
CAS No.
530-50-7
Chemical Name
1,1-DIPHENYLHYDRAZINE
Synonyms
Ai3-23023;Ccris 4562;Brn 0957349;hydrozobenzene;Einecs 208-483-1;1,1-diphenyl-hydrazin;1,1-DIPHENYLHYDRAZINE;hydrazine,1,1-diphenyl;unsym-Diphenylhydrazine;asym-Diphenyl hydrazine
CBNumber
CB5695102
Molecular Formula
C12H12N2
Formula Weight
184.24
MOL File
530-50-7.mol
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1,1-DIPHENYLHYDRAZINE Property

Melting point:
50.5°C
Boiling point:
308.2°C (rough estimate)
Density 
1,12 g/cm3
refractive index 
1.6266 (estimate)
pka
3.34±0.10(Predicted)
form 
powder to lump to clear liquid
color 
White or Colorles to Yellow to Orange
Merck 
14,3325
CAS DataBase Reference
530-50-7(CAS DataBase Reference)
EPA Substance Registry System
1,1-Diphenylhydrazine (530-50-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
RTECS 
MV3450000
HS Code 
2928009090
Hazardous Substances Data
530-50-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS000251
Product name
1,1-Diphenylhydrazine
Purity
AldrichCPR
Packaging
250MG
Price
$68.1
Updated
2023/06/20
TCI Chemical
Product number
D1161
Product name
1,1-Diphenylhydrazine
Purity
>97.0%(GC)(T)
Packaging
5mL
Price
$159
Updated
2024/03/01
TRC
Product number
B431150
Product name
1,1-diphenylhydrazine
Packaging
500mg
Price
$110
Updated
2021/12/16
TRC
Product number
B431150
Product name
1,1-diphenylhydrazine
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD166510
Product name
1,1-Diphenylhydrazine
Packaging
50g
Price
$1500
Updated
2021/12/16
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1,1-DIPHENYLHYDRAZINE Chemical Properties,Usage,Production

Description

Diphenylhydrazine is a man-made chemical that occurs in two isomeric forms: 1,1-diphenylhydrazine and 1,2-diphenylhdrazine. Diphenylhydrazine is produced by the reduction of nitrobenzene. Little or no information is available for 1,1-diphenylhydrazine. Most toxicological and use data pertain to 1,2-diphenylhydrazine.

Uses

Previously, 1,2-diphenylhydrazine was used for producing benzidine that was used in the synthesis of benzidine-based dyes. However, these dyes are no longer produced in the United States. The primary use of 1,2-diphenylhydrazine is in the production of the anti-inflammatory agent phenylbutazone and sulfinpyrazone, a uricosuric agent.

Synthesis Reference(s)

The Journal of Organic Chemistry, 33, p. 3963, 1968 DOI: 10.1021/jo01274a068

General Description

Yellow crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Toxic gases may be formed by mixing 1,1-DIPHENYLHYDRAZINE with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Environmental Fate

Definitive information regarding the environmental fate and behavior of diphenylhydrazine in environmental media is extremely limited. No information is available affirming persistence of diphenylhydrazine in the environment or definitive pathways for its degradation. The low vapor pressure of diphenylhydrazine precludes it being a significant air contaminant. Diphenylhydrazine may be moderately absorbed into soil but it would be quickly oxidized to azobenzene. The half-life of diphenylhydrazine in water is reportedly less than 15 min and is likely due to its oxidation to azobenzene and benzidine.

Purification Methods

Purify it via the hydrochloride [530-47-2], which has m 165-170o(dec) after crystallization from aqueous EtOH (+ a few drops of HCl) and recover the free base with aqueous NaOH, extract it into Et2O, dry it (KOH), filter, evaporate and distil the residue under a vacuum. The distillate crystallises on cooling. The benzoyl derivative has m 194o (from Me2CO), and the 4-nitrophenyl hydrazone (with the aldehyde) has m 131-132o. [Koga & Anselme J Org Chem 33 3963 1968, Beilstein 15 IV 55.]

Toxicity evaluation

The mechanism of action of diphenylhydrazine is not known. It is possible that some toxic effects may be attributed to its major metabolites, aniline and azobenzene, both of which are known carcinogens. Results of metabolism studies reporting aniline, benzidine, hyroxybenzidines, and aminophenols as metabolites in rats following multiple routes of administration suggest that the diphenylhydrazine metabolism may be similar to that of azobenzene and aniline. It is also possible that conversion of 1,2-diphenylhydrazine to aniline in the gastrointestinal tract may occur due to intestinal microflora and via acid hydrolysis.

1,1-DIPHENYLHYDRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1-DIPHENYLHYDRAZINE Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
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86-21-61259102
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market03@meryer.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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03-3668-0520
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Sales-JP@TCIchemicals.com
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Japan
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28398
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TCI Europe
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320-37350700
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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23680
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TCI AMERICA
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800-4238616
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+1-888-520-1075 / +1-503-283-1987
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sales@tciamerica.com
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Americas
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9ding chemical ( Shanghai) Limited
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4009209199
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China
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22519
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Chengdu HuaXia Chemical Reagent Co. Ltd
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400-1166-196 13458535857
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QQ:800101999
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cdhxsj@163.com
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China
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Shanghai Shenmin Industrial Co., Ltd.
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13601649268; 13601649268
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xingui2022@126.com
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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530-50-7, 1,1-DIPHENYLHYDRAZINERelated Search:


  • 1,1-diphenyl-hydrazin
  • alpha,alpha-Diphenylhydrazine
  • Hydrazine, 1,1-diphenyl-
  • hydrazine,1,1-diphenyl
  • hydrazine,1,1-diphenyl-
  • hydrozobenzene
  • asym-Diphenyl hydrazine
  • 1,1-DIPHENYLHYDRAZINE
  • N,N-Diphenylhydrazine~90%
  • 1,1-DIPHENYLHYDRAZINE 95+%
  • unsym-Diphenylhydrazine
  • 530-47-2 (Hydrochloride)
  • 530-47-2 (Mono-hydrochloride)
  • Ai3-23023
  • Brn 0957349
  • Ccris 4562
  • Einecs 208-483-1
  • 1,1-Diphenylhydrazine AldrichCPR
  • 1,1-Diphenylhydrazine &gt
  • 530-50-7
  • C6H52NNH2
  • C6H5NHNHC6H5