1,1-DIPHENYLHYDRAZINE
- Product Name
- 1,1-DIPHENYLHYDRAZINE
- CAS No.
- 530-50-7
- Chemical Name
- 1,1-DIPHENYLHYDRAZINE
- Synonyms
- Ai3-23023;Ccris 4562;Brn 0957349;hydrozobenzene;Einecs 208-483-1;1,1-diphenyl-hydrazin;1,1-DIPHENYLHYDRAZINE;hydrazine,1,1-diphenyl;unsym-Diphenylhydrazine;asym-Diphenyl hydrazine
- CBNumber
- CB5695102
- Molecular Formula
- C12H12N2
- Formula Weight
- 184.24
- MOL File
- 530-50-7.mol
1,1-DIPHENYLHYDRAZINE Property
- Melting point:
- 50.5°C
- Boiling point:
- 308.2°C (rough estimate)
- Density
- 1,12 g/cm3
- refractive index
- 1.6266 (estimate)
- pka
- 3.34±0.10(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorles to Yellow to Orange
- Merck
- 14,3325
- CAS DataBase Reference
- 530-50-7(CAS DataBase Reference)
- EPA Substance Registry System
- 1,1-Diphenylhydrazine (530-50-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- RTECS
- MV3450000
- HS Code
- 2928009090
- Hazardous Substances Data
- 530-50-7(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS000251
- Product name
- 1,1-Diphenylhydrazine
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $68.1
- Updated
- 2023/06/20
- Product number
- D1161
- Product name
- 1,1-Diphenylhydrazine
- Purity
- >97.0%(GC)(T)
- Packaging
- 5mL
- Price
- $159
- Updated
- 2024/03/01
- Product number
- B431150
- Product name
- 1,1-diphenylhydrazine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- B431150
- Product name
- 1,1-diphenylhydrazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD166510
- Product name
- 1,1-Diphenylhydrazine
- Packaging
- 50g
- Price
- $1500
- Updated
- 2021/12/16
1,1-DIPHENYLHYDRAZINE Chemical Properties,Usage,Production
Description
Diphenylhydrazine is a man-made chemical that occurs in two isomeric forms: 1,1-diphenylhydrazine and 1,2-diphenylhdrazine. Diphenylhydrazine is produced by the reduction of nitrobenzene. Little or no information is available for 1,1-diphenylhydrazine. Most toxicological and use data pertain to 1,2-diphenylhydrazine.
Uses
Previously, 1,2-diphenylhydrazine was used for producing benzidine that was used in the synthesis of benzidine-based dyes. However, these dyes are no longer produced in the United States. The primary use of 1,2-diphenylhydrazine is in the production of the anti-inflammatory agent phenylbutazone and sulfinpyrazone, a uricosuric agent.
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 3963, 1968 DOI: 10.1021/jo01274a068
General Description
Yellow crystals. Insoluble in water.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Toxic gases may be formed by mixing 1,1-DIPHENYLHYDRAZINE with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Environmental Fate
Definitive information regarding the environmental fate and behavior of diphenylhydrazine in environmental media is extremely limited. No information is available affirming persistence of diphenylhydrazine in the environment or definitive pathways for its degradation. The low vapor pressure of diphenylhydrazine precludes it being a significant air contaminant. Diphenylhydrazine may be moderately absorbed into soil but it would be quickly oxidized to azobenzene. The half-life of diphenylhydrazine in water is reportedly less than 15 min and is likely due to its oxidation to azobenzene and benzidine.
Purification Methods
Purify it via the hydrochloride [530-47-2], which has m 165-170o(dec) after crystallization from aqueous EtOH (+ a few drops of HCl) and recover the free base with aqueous NaOH, extract it into Et2O, dry it (KOH), filter, evaporate and distil the residue under a vacuum. The distillate crystallises on cooling. The benzoyl derivative has m 194o (from Me2CO), and the 4-nitrophenyl hydrazone (with the aldehyde) has m 131-132o. [Koga & Anselme J Org Chem 33 3963 1968, Beilstein 15 IV 55.]
Toxicity evaluation
The mechanism of action of diphenylhydrazine is not known. It is possible that some toxic effects may be attributed to its major metabolites, aniline and azobenzene, both of which are known carcinogens. Results of metabolism studies reporting aniline, benzidine, hyroxybenzidines, and aminophenols as metabolites in rats following multiple routes of administration suggest that the diphenylhydrazine metabolism may be similar to that of azobenzene and aniline. It is also possible that conversion of 1,2-diphenylhydrazine to aniline in the gastrointestinal tract may occur due to intestinal microflora and via acid hydrolysis.
1,1-DIPHENYLHYDRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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