3-BENZYLIDENE-2,4-PENTANEDIONE Property

Melting point:

169 °C

Boiling point:

185-188 °C/15 mmHg (lit.)

Density 

1.081 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.583(lit.)

Flash point:

>230 °F

form 

liquid

Specific Gravity

1.081

BRN 

972849

CAS DataBase Reference

4335-90-4(CAS DataBase Reference)

EPA Substance Registry System

2,4-Pentanedione, 3-(phenylmethylene)- (4335-90-4)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

SA1930000

TSCA 

Yes

HS Code 

2914390090

Toxicity

mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08898,

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-BENZYLIDENE-2,4-PENTANEDIONE Chemical Properties,Usage,Production

Uses

3-Benzylidene-2,4-pentanedione may be used in the preparation of:

• Five membered cyclic oxyphosphoranes by reacting with phosphonite esters.
• 5-Hydroxy-N-substituted-2H-pyrrol-2-ones by reacting with alkyl isocyanides.
• 3-Benzylidene-2,4-bis (trimethylsilyloxy)-1,4-pentadiene via trimethylsilylation.

Synthesis Reference(s)

Synthetic Communications, 26, p. 3025, 1996 DOI: 10.1080/00397919608004607

General Description

3-Benzylidene-2,4-pentanedione (BPD) can be prepared by reacting benzaldehyde with 2,4-pentanedione in the presence of a base.