CARVEDILOL-D5

Product Name: CARVEDILOL-D5
CAS No.: 929106-58-1
Chemical Name: CARVEDILOL-D5
Synonyms: CARVEDILOL-D5;Carvedilol-d5 N’-?-D-Glucuronide;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5
CBNumber: CB5704859
Molecular Formula: C24H21D5N2O4
Formula Weight: 411.51
MOL File: Mol file

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CARVEDILOL-D5 Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
form: A solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25218
Product name: Carvedilol-d5
Purity: ≥99% deuterated forms (d1-d5)
Packaging: 500μg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 25218
Product name: Carvedilol-d5
Purity: ≥99% deuterated forms (d1-d5)
Packaging: 1mg
Price: $184
Updated: 2024/03/01

Usbiological

Product number: 005808
Product name: Carvedilol-d5
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: C184628
Product name: Carvedilol-d5
Packaging: 10mg
Price: $1455
Updated: 2021/12/16

AK Scientific

Product number: 8725DF
Product name: Carvedilol-d5
Packaging: 1mg
Price: $302
Updated: 2021/12/16

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CARVEDILOL-D5 Chemical Properties,Usage,Production

Description

Carvedilol-d₅ is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; K_ds = 1.78, 0.4, and 5.01 nM for β₁-, β₂-, and β₃-ARs, respectively). It also binds to α₁-, but not α₂-, adrenergic receptors (K_is = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β₁-AR agonist isoproterenol in isolated guinea pig atria (K_b = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (K_b = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED₅₀ value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α₁-AR agonist norepinephrine in isolated rabbit aorta (K_b = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.

Chemical Properties

White Solid

Uses

Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.

Uses

Labeled Carvedilol, intended for use as an internal standard for the quantification of Carvedilol by GC- or LC-mass spectrometry.

CARVEDILOL-D5 Preparation Products And Raw materials

Raw materials

Preparation Products

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CARVEDILOL-D5 Suppliers

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929106-58-1, CARVEDILOL-D5Related Search:

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CARVEDILOL-D5

1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5

Carvedilol-d5 N’-?-D-Glucuronide

929106-58-1

C24H21D5N2O4

Isotope