ChemicalBook > CAS DataBase List > 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT

2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT

Product Name
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
CAS No.
80902-29-0
Chemical Name
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
Synonyms
Rp-dGTPαS;SP-DGTP-ALPHA-S SODIUM SALT;RP-DGTP-ALPHA-S SODIUM SALT;dGTPαS (Rp isomer) 100mM Sodium Solution;Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt);Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt);2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT;2’-deoxyguanosine-5’-o-(1-thiotriphosphate),rpisomer(rp-dgtp-alpha-s),sodiumsalt;Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))
CBNumber
CB5705700
Molecular Formula
C10H12N5Na4O12P3S
Formula Weight
611.17
MOL File
80902-29-0.mol
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2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Property

Density 
2.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
solubility 
Water: Soluble
pka
1.07±0.10(predicted)
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Hazard and Precautionary Statements (GHS)

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2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Chemical Properties,Usage,Production

Uses

Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1].

References

[1] Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60(21):1682-1698. DOI:10.1021/acs.biochem.0c00944

2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Suppliers

China 7 Germany 1 Global 8
Jiangsu Synthgene Biotechnology Co.,Ltd.
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15852554546
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Cayman Chemical Company
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Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060
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Shanghai meikai technology co., ltd
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021-68689288 15300790979
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80902-29-0, 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALTRelated Search:

2'-Deoxyguanosine monohydrate α-2'-Deoxyguanosine

  • 2’-deoxyguanosine-5’-o-(1-thiotriphosphate),rpisomer(rp-dgtp-alpha-s),sodiumsalt
  • RP-DGTP-ALPHA-S SODIUM SALT
  • SP-DGTP-ALPHA-S SODIUM SALT
  • 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
  • 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT
  • Guanosine, 2'-deoxy-, 5'→P''-ester with [P''(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)) (9CI)
  • dGTPαS (Rp isomer) 100mM Sodium Solution
  • Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))
  • Rp-dGTPαS
  • Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt)
  • Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt)
  • 80902-29-0