ChemicalBook > CAS DataBase List > N-Acetyl-L-valine
N-Acetyl-L-valine
- Product Name
- N-Acetyl-L-valine
- CAS No.
- 96-81-1
- Chemical Name
- N-Acetyl-L-valine
- Synonyms
- AC-VAL-OH;AC-VALINE;Ac-Veu-OH;Ac-L-Val-OH;Acetylvaline;N-Ac-L-Val-OH;ACETYL-L-VALINE;N-ACETYL-L-VALINE;L-Valine, N-acetyl-;N-α-Actetyl-L-valine
- CBNumber
- CB5716614
- Molecular Formula
- C7H13NO3
- Formula Weight
- 159.18
- MOL File
- 96-81-1.mol
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N-Acetyl-L-valine Property
- Melting point:
- 163-167℃
- alpha
- [α]D20 -16～-20゜ (c=5, C2H5OH)
- Boiling point:
- 362.2±25.0 °C(Predicted)
- Density
- 1.094±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- pka
- 3.62±0.10(Predicted)
- color
- White
- optical activity
- -18° (C=0.01 g/ml, H2O)
- InChI
- InChI=1S/C7H13NO3/c1-4(2)6(7(10)11)8-5(3)9/h4,6H,1-3H3,(H,8,9)(H,10,11)/t6-/m0/s1
- InChIKey
- IHYJTAOFMMMOPX-LURJTMIESA-N
- SMILES
- C(O)(=O)[C@H](C(C)C)NC(C)=O
- CAS DataBase Reference
- 96-81-1(CAS DataBase Reference)
- NIST Chemistry Reference
- L-valine, n-acetyl-(96-81-1)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 806463
- Product name
- N-Acetyl-L-valine
- Packaging
- 250mg
- Price
- $40.5
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A2366
- Product name
- N-Acetyl-L-valine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
TCI Chemical
- Product number
- A2366
- Product name
- N-Acetyl-L-valine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $46
- Updated
- 2025/07/31
TRC
- Product number
- A192393
- Product name
- N-Acetyl-L-valine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Usbiological
- Product number
- 260558
- Product name
- Acetyl-L-valine
- Packaging
- 25g
- Price
- $347
- Updated
- 2021/12/16
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N-Acetyl-L-valine Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
Ac-Val-OH may be employed as a ligand for the meta-selective tert-alkylation reaction.
Definition
ChEBI: An L-valine derivative in which one of the amino hydrogens of L-valine has been replaced by an acetyl group.
General Description
Ac-Val-OH is an N-protected valine amino acid ligand. It participates in the 2,6-diolefination reaction of phenylacetic acids.
Synthesis
72-18-4
108-24-7
96-81-1
The general procedure for the synthesis of N-acetyl-L-valine from L-valine and acetic anhydride was as follows: L-valine (200 g, 1.7 mol) was dissolved in distilled water (500 mL), followed by the addition of 30% sodium hydroxide solution (170 mL). After cooling the reaction mixture to 0-5°C, acetic anhydride (32 mL, 1.4 eq.) was added slowly and dropwise. This was repeated six times (total acetic anhydride: 6 x 32 mL; 30% sodium hydroxide solution: 6 x 34 mL) by alternating dropwise additions of 30% sodium hydroxide solution (34 mL) and acetic anhydride (32 mL) while maintaining the temperature at 0-5°C. After the addition was completed, the reaction mixture continued to be stirred at 0°C for 2 hours. Subsequently, 32% hydrochloric acid (380 mL) was slowly added to adjust the pH to below 3 while maintaining the reaction temperature at 0°C. The resulting slurry was allowed to crystallize for 12 h. The solid product was collected by filtration and the filter cake was washed with 0.1 N hydrochloric acid (100 mL). Finally, the wet N-acetyl-L-valine was dried to give 233 g of white crystalline solid in 86% yield.
IC 50
Human Endogenous Metabolite
References
[1] New Journal of Chemistry, 2002, vol. 26, # 7, p. 834 - 843
[2] Synthetic Communications, 1992, vol. 22, # 2, p. 257 - 264
[3] Patent: WO2005/40097, 2005, A1. Location in patent: Page/Page column 9
[4] Journal of the American Chemical Society, 2011, vol. 133, # 43, p. 17176 - 17179
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 4636,4642
N-Acetyl-L-valine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Acetyl-L-valine manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- N-Acetyl-L-valine 96-81-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-Acetyl-L-valine 96-81-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-Acetyl-L-valine 96-81-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
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