GSK-3 β inhibitor 2
- Product Name
- GSK-3 β inhibitor 2
- CAS No.
- 1702428-31-6
- Chemical Name
- GSK-3 β inhibitor 2
- Synonyms
- GSK-3β inhibitor 2;GSK-3 β inhibitor 2;2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide;5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-;2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide?, GSK-3β inhibitor 2
- CBNumber
- CB57247236
- Molecular Formula
- C14H14N4O3S
- Formula Weight
- 318.35
- MOL File
- 1702428-31-6.mol
GSK-3 β inhibitor 2 Property
- Density
- 1.475±0.06 g/cm3(Predicted)
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
- form
- Solid
- pka
- 13.08±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0113735
- Product name
- GSK-3βinhibitor2
- Purity
- 98.82%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0113735
- Product name
- GSK-3βinhibitor2
- Purity
- 98.82%
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-0113735
- Product name
- GSK-3βinhibitor2
- Purity
- 98.82%
- Packaging
- 50mg
- Price
- $1600
- Updated
- 2021/12/16
- Product number
- CS-0113735
- Product name
- GSK-3βinhibitor2
- Purity
- 98.82%
- Packaging
- 100mg
- Price
- $2400
- Updated
- 2021/12/16
- Product number
- A1329215
- Product name
- 2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide
- Purity
- 98%
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
GSK-3 β inhibitor 2 Chemical Properties,Usage,Production
Uses
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease[1].
in vivo
The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point[1].
IC 50
GSK-3β: 1.1 nM (IC50)
References
[1] Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. DOI:10.1016/j.bmcl.2015.03.046
GSK-3 β inhibitor 2 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-3 β inhibitor 2 Suppliers
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 13816613772
- Fax
- QQ: 12922499
- huahero21@sina.com
- Country
- China
- ProdList
- 2495
- Advantage
- 55
- Tel
- 13761635123
- Fax
- 1014988033@qq
- sales@linyuepharm.com
- Country
- China
- ProdList
- 5006
- Advantage
- 55
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32470
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 18130062233
- 3362556465@qq.com
- Country
- China
- ProdList
- 8100
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24964
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 5975
- Advantage
- 58