OATD-01
- Product Name
- OATD-01
- CAS No.
- 2088453-21-6
- Chemical Name
- OATD-01
- Synonyms
- OATD-01;OATD-01, 10 mM in DMSO;5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine;inhibit,CHIT1,OATD-01,chitinase,antifibrotic,IPF,pulmonary fibrosis,OATD01,OATD 01,Inhibitor;1H-1,2,4-Triazol-3-amine, 5-[4-[(2S,5S)-5-[(4-chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-
- CBNumber
- CB57247241
- Molecular Formula
- C19H27ClN6O
- Formula Weight
- 390.91
- MOL File
- 2088453-21-6.mol
OATD-01 Property
- Boiling point:
- 586.4±60.0 °C(Predicted)
- Density
- 1.297±0.06 g/cm3(Predicted)
- solubility
- DMSO:100.0(Max Conc. mg/mL);255.81(Max Conc. mM)
- form
- A solid
- pka
- 12.86±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
OATD-01 Chemical Properties,Usage,Production
Uses
OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research[1].
in vivo
OATD-01 (oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days) shows significant antifibrotic efficacy in an animal model of Bleomycin (HY-108345)-induced pulmonary fibrosis. It reduces the degree of lung fibrosis in a dose-dependent manner, ultimately achieving comparable therapeutic efficacy to reference treatment with Nintedanib (HY-50904) in this animal model[1].
| Animal Model: | Female BALB/c mice[1] |
| Dosage: | 30 mg/kg, 100 mg/kg |
| Administration: | Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days |
| Result: | Reduced the degree of lung fibrosis in vivo[1] |
References
[1] Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540. DOI:10.1021/acs.jmedchem.0c01179
OATD-01 Preparation Products And Raw materials
Raw materials
Preparation Products
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