ChemicalBook > CAS DataBase List > 4-(TRIFLUOROMETHYL)NICOTINAMIDE

4-(TRIFLUOROMETHYL)NICOTINAMIDE

Product Name
4-(TRIFLUOROMETHYL)NICOTINAMIDE
CAS No.
158062-71-6
Chemical Name
4-(TRIFLUOROMETHYL)NICOTINAMIDE
Synonyms
TFNA-AM;TFNA-AM Standard;Nicotinamide Impurity 129;TFNA-AM 10.0 μg/ml Acetonitrile;4-(TRIFLUOROMETHYL)NICOTINAMIDE;Trifluoromethylpyridinecarboxamide2;4-Trifluoromethylpyridin-3-carboxamide;4-trifluoroMethyl-3-pyridinecarboxaMide;4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXAMIDE;3-Pyridinecarboxamide, 4-(trifluoromethyl)-
CBNumber
CB5726965
Molecular Formula
C7H5F3N2O
Formula Weight
190.12
MOL File
158062-71-6.mol
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4-(TRIFLUOROMETHYL)NICOTINAMIDE Property

Melting point:
165°C
Boiling point:
292.0±40.0 °C(Predicted)
Density 
1.409±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
14.29±0.50(Predicted)
color 
White to Off-White
InChI
InChI=1S/C7H5F3N2O/c8-7(9,10)5-1-2-12-3-4(5)6(11)13/h1-3H,(H2,11,13)
InChIKey
JUIWZYBJXUPIKF-UHFFFAOYSA-N
SMILES
C1=NC=CC(C(F)(F)F)=C1C(N)=O
CAS DataBase Reference
158062-71-6(CAS DataBase Reference)
EPA Substance Registry System
3-Pyridinecarboxamide, 4-(trifluoromethyl)- (158062-71-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T791315
Product name
4-(Trifluoromethyl)nicotinamide
Packaging
1g
Price
$135
Updated
2021/12/16
Matrix Scientific
Product number
012547
Product name
4-(Trifluoromethyl)nicotinamide
Purity
98%
Packaging
1g
Price
$161
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-3-0U
Product name
4-(Trifluoromethyl)nicotinamide
Packaging
1g
Price
$168
Updated
2021/12/16
Oakwood
Product number
023451
Product name
4-(Trifluoromethyl)nicotinamide
Purity
98%
Packaging
1g
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
PC10153
Product name
4-(Trifluoromethyl)nicotinamide
Packaging
1g
Price
$105
Updated
2021/12/16
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4-(TRIFLUOROMETHYL)NICOTINAMIDE Chemical Properties,Usage,Production

Uses

4-(Trifluoromethyl)nicotinamide (TFNA-AM) is a metabolite of Flonicamid (F405710); a novel insecticide with rapid inhibitory effect against aphid feeding.

Synthesis

533932-97-7

533932-96-6

158062-71-6

Sodium hydroxide (600 mg, 15 mmol) was added as 3-[(4,4,4-trifluoro-3-oxo-1-butenyl)amino]-2-propenenitrile (mixture of IIa and IIb, 1.90 g, 10 mmol) and methanol (15 mL). The reaction mixture was heated to reflux for 6 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with hexane/acetone (1:1, v/v) as eluent to afford 4-(trifluoromethyl)nicotinamide (1.25 g, 65.6% yield). The product was characterized by 1H-NMR (200 MHz, DMSO-d6): δ 8.89 (1H, d, J = 5.1 Hz), 8.82 (1H, s), 8.18 (1H, brs), 7.85 (1H, brs), 7.81 (1H, d, J = 5.1 Hz).

References

[1] Patent: EP1460071, 2004, A1. Location in patent: Page 39
[2] Patent: EP1460071, 2004, A1. Location in patent: Page 40
[3] Patent: EP1460071, 2004, A1. Location in patent: Page 40

4-(TRIFLUOROMETHYL)NICOTINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(TRIFLUOROMETHYL)NICOTINAMIDE Suppliers

China 129 France 1 Germany 1 India 4 Japan 1 Ukraine 1 United Kingdom 9 United States 9 Global 155
Suzhou Hongrui Biotechnology Co., Ltd
Tel
18115505569; 18115505569
Email
hongrui@163.cn
Country
China
ProdList
13
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
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View Lastest Price from 4-(TRIFLUOROMETHYL)NICOTINAMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-(TRIFLUOROMETHYL)NICOTINAMIDE 158062-71-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
4-(TRIFLUOROMETHYL)NICOTINAMIDE 158062-71-6
Price
US $30.00-12.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-07
Career Henan Chemical Co
Product
4-(TRIFLUOROMETHYL)NICOTINAMIDE 158062-71-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

158062-71-6, 4-(TRIFLUOROMETHYL)NICOTINAMIDERelated Search:

4-(TRIFLUOROMETHYL)NICOTINAMIDE 4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE 2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE 2-METHOXY-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXAMIDE 2-METHOXY-4-(TRIFLUOROMETHYL)PYRIDINE-5-CARBOXAMIDE 2-CHLORO-5-NITRO-6-(3-NITROPHENYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE N3-(2,4-DICHLOROBENZYL)-N3-PROPYL-6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE 2-CHLORO-N-(2,4-DICHLOROBENZYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE 6-CHLORO-N-[2-(3-CHLOROPHENYL)-2-OXOETHYL]-4-(TRIFLUOROMETHYL)NICOTINAMIDE 2-CHLORO-N-(2,4-DICHLORO-6-METHYLBENZYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE 2-CHLORO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE 6-CHLORO-N-(2,4-DICHLORO-6-METHYLBENZYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE N-[[[(2,6-DIMETHOXYBENZYL)AMINO]CARBONYL]METHYL]-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXAMIDE 6-CHLORO-N'-(3-CHLOROBENZOYL)-4-(TRIFLUOROMETHYL)NICOTINOHYDRAZIDE N3-[2-(4-CHLOROPHENYL)-2-OXOETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE N3-(2,4-DIFLUOROPHENYL)-2-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE 6-CHLORO-N-(4-METHOXYBENZYL)-4-(TRIFLUOROMETHYL)NICOTINAMIDE N-ETHYL-N-PHENYL-4-(TRIFLUOROMETHYL)NICOTINAMIDE

  • 4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXAMIDE
  • 4-(TRIFLUOROMETHYL)NICOTINAMIDE
  • Trifluoromethylpyridinecarboxamide2
  • 4-trifluoroMethyl-3-pyridinecarboxaMide
  • FlonicaMide Metabolite (TFNA-AM type, 4-TriuoroMethylnicotin aMide)
  • 3-Pyridinecarboxamide, 4-(trifluoromethyl)-
  • TFNA-AM
  • TFNA-AM Standard
  • TFNA-AM 10.0 μg/ml Acetonitrile
  • 4-Trifluoromethylnicotinamide in Acetonitrile
  • Nicotinamide Impurity 129
  • 4-Trifluoromethylnicotinamide 100 μg/mL in Acetonitrile
  • 4-Trifluoromethylpyridin-3-carboxamide
  • 158062-71-6