2-(4-BROMOPHENOXY)ACETONITRILE

2-(4-BROMOPHENOXY)ACETONITRILE Property

Melting point:

52-54 °C

Boiling point:

303.1±17.0 °C(Predicted)

Density 

1.519±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

form 

solid

color 

Brown

Safety

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

UN3439

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

2926907090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

2-(4-BROMOPHENOXY)ACETONITRILE Chemical Properties,Usage,Production

Synthesis

4-Bromophenol (10 g, 57.8 mmol), Cs2CO3 (24.48 g, 75.14 mmol) and chloroacetonitrile (5.66 g, 75.14 mmol) were dissolved in DMF. The mixture was then heated to 70°C for 5 hours, and transferred into a mixture of ice/H2O. The precipitate was filtered, and the resulting solid was partitioned between water and DCM. The aqueous phase was back extracted and the combined organic phases were washed with brine, dried over Na2SO4 and the solvent removed under reduced atmosphere, resulting a beige solid 2-(4-BROMOPHENOXY)ACETONITRILE. Yield: 12.18 g, 57.4 mmol (99% based on 4-bromophenol).