HOECHST 34580

ChemicalBook > CAS DataBase List > HOECHST 34580

Product Name: HOECHST 34580
CAS No.: 23555-00-2
Chemical Name: HOECHST 34580
Synonyms: ProaMine;HOE 34580;HOECHST 34580;Hoechst 34580 (HOE 34580);2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
CBNumber: CB5729663
Molecular Formula: C27H29N7
Formula Weight: 451.57
MOL File: 23555-00-2.mol

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HOECHST 34580 Property

Melting point:: >300℃
Boiling point:: 733.2±70.0 °C(Predicted)
Density: 1.280±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in dimethyl sulfoxide, water
form: powder
pka: 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃)
color: Yellow to green
λmax: 392nm
Biological Applications: Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: CDX-B0094-M005
Product name: Hoechst 34580
Purity: ≥98%(HPLC)
Packaging: 5mg
Price: $59
Updated: 2021/12/16

ChemScene

Product number: CS-1303
Product name: Hoechst 34580
Purity: 99.84%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

ChemScene

Product number: CS-1303
Product name: Hoechst 34580
Purity: 99.84%
Packaging: 10mg
Price: $108
Updated: 2021/12/16

ApexBio Technology

Product number: A3475
Product name: Hoechst 34580
Packaging: 25mg
Price: $112
Updated: 2021/12/16

ChemScene

Product number: CS-1303
Product name: Hoechst 34580
Purity: 99.84%
Packaging: 50mg
Price: $288
Updated: 2021/12/16

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HOECHST 34580 Chemical Properties,Usage,Production

Biological Activity

Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye used to stain DNA and cell nuclei. It is also a good candidate for the treatment of Alzheimer's disease by inhibiting the formation of amyloid beta (Aβ) with an IC50 value of 0.86 μM.

in vitro

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC ₅₀ of 0.86±0.05 μM for Hoechst 34580. It is a good candidate for treating the Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose- dependent manner. And the half-maximal concentration (IC ₅₀ ) is examined. The IC ₅₀ is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86 ±0.05 μM for Hoechst 34580.

target

Target	Value
Aβ (Cell-free assay)	0.86 μM

HOECHST 34580 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOECHST 34580 Suppliers

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23555-00-2, HOECHST 34580Related Search:

HOECHST 34580

HOE 34580

ProaMine

2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-

Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-

Hoechst 34580 (HOE 34580)

N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline

23555-00-2

C27H32Cl3N7

C27H29N7

Benzimidazole