4-TRIMETHYLSILYLBENZALDEHYDE
- Product Name
- 4-TRIMETHYLSILYLBENZALDEHYDE
- CAS No.
- 2199-32-8
- Chemical Name
- 4-TRIMETHYLSILYLBENZALDEHYDE
- Synonyms
- 4-TRIMETHYLSILYLBENZALDEHYDE;Benzaldehyde, 4-(trimethylsilyl)-
- CBNumber
- CB5733886
- Molecular Formula
- C10H14OSi
- Formula Weight
- 178.3
- MOL File
- 2199-32-8.mol
4-TRIMETHYLSILYLBENZALDEHYDE Property
- Melting point:
- 109-110 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 119 °C(Press: 15 Torr)
- Density
- 0.9960 g/cm3(Temp: 425 °C)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Z4422
- Product name
- 4-(Trimethylsilyl)benzaldehyde
- Packaging
- 100mg
- Price
- $236
- Updated
- 2021/12/16
- Product number
- Z4422
- Product name
- 4-(Trimethylsilyl)benzaldehyde
- Packaging
- 250mg
- Price
- $251
- Updated
- 2021/12/16
- Product number
- 094931
- Product name
- 4-(Trimethylsilyl)benzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $341
- Updated
- 2021/12/16
- Product number
- ING0003607
- Product name
- 4-TRIMETHYLSILYLBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $365.4
- Updated
- 2021/12/16
- Product number
- 094931
- Product name
- 4-(Trimethylsilyl)benzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $924
- Updated
- 2021/12/16
4-TRIMETHYLSILYLBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis
6999-03-7
68-12-2
2199-32-8
General procedure: 1-bromo-4-trimethylsilylbenzene (1.15 g, 5 mmol) was dissolved in tetrahydrofuran (THF, 30 mL) and the solution was cooled to -78 °C. Under argon protection, a hexane solution of 1.6 M n-butyllithium (3.13 mL, 5 mmol) was cooled to -78 °C and slowly added dropwise to the reaction solution, keeping the reaction temperature below -70 °C. After dropwise addition, the resulting clarified colorless solution was stirred at -78 °C for 15 min, followed by rapid addition of N,N-dimethylformamide (DMF, 1.156 mL, 15 mmol). The temperature of the reaction mixture was raised to -68 °C and stirring was continued at -78 °C for 15 min. Upon completion of the reaction, the reaction was quenched with 1 N aqueous hydrochloric acid and extracted twice with ether. The organic layers were combined and washed sequentially with water twice, saturated aqueous sodium chloride once, and then dried with anhydrous sodium sulfate. After filtration, the solvent was removed by evaporation to give 4-trimethylsilylbenzaldehyde as a colorless oil (920 mg, 100% yield). The product was sufficiently pure to be used directly in the subsequent reaction. Mass spectrum (ISP) m/z: 179.2 ([M + H]+). 1H NMR (CDCl3, 300 MHz) δ: 10.02 (s, 1H), 7.84 (d, J = 8.1 Hz, 2H), 7.69 (d, J = 8.1 Hz, 2H), 0.31 (s, 9H).
References
[1] Patent: US2007/185058, 2007, A1. Location in patent: Page/Page column 9
[2] Dyes and Pigments, 2017, vol. 141, p. 128 - 136
[3] Macromolecules, 2003, vol. 36, # 18, p. 6807 - 6816
[4] Tetrahedron, 2003, vol. 59, # 20, p. 3593 - 3601
[5] Organic Letters, 2010, vol. 12, # 21, p. 4728 - 4731
4-TRIMETHYLSILYLBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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