ChemicalBook > CAS DataBase List > 2,6-Dichloro-5-fluoronicotinamide

2,6-Dichloro-5-fluoronicotinamide

Product Name
2,6-Dichloro-5-fluoronicotinamide
CAS No.
113237-20-0
Chemical Name
2,6-Dichloro-5-fluoronicotinamide
Synonyms
2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE;2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine;CPD2809-A1;Sotorasib Impurity 1;Olutasidenib Impurity 32;2,6-DICHLORO-5-FLUORONICOTIMIDE;2,6-DICHLORO-5-FLUORONICOTINAMIDE;2,6-Dichloro-5-fluoronicotinamide97%;2,6-Dichloro-5-fluoronicotinamide 97%;2,6-Dichloro-3-formamide-5-fluoropyridine
CBNumber
CB5735729
Molecular Formula
C6H3Cl2FN2O
Formula Weight
209.01
MOL File
113237-20-0.mol
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2,6-Dichloro-5-fluoronicotinamide Property

Melting point:
160-162
Boiling point:
259.0±40.0 °C(Predicted)
Density 
1.614±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline solid
pka
13.36±0.50(Predicted)
color 
White
InChI
InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12)
InChIKey
ZVYNUGSPFZCYEV-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=C(F)C=C1C(N)=O
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B419340
Product name
2,6-Dichloro-5-fluoronicotinamide
Packaging
500mg
Price
$175
Updated
2021/12/16
TRC
Product number
B419340
Product name
2,6-Dichloro-5-fluoronicotinamide
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC6948
Product name
2,6-Dichloro-5-fluoronicotinamide
Purity
98%
Packaging
25g
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0010906
Product name
2,6-DICHLORO-5-FLUORONICOTINAMIDE
Purity
95.00%
Packaging
5G
Price
$1449.29
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD81079
Product name
2,6-Dichloro-5-Fluoronicotinamide
Packaging
25g
Price
$550
Updated
2021/12/16
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2,6-Dichloro-5-fluoronicotinamide Chemical Properties,Usage,Production

Uses

2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer.

Synthesis

A reaction vessel added 2000 mL of phosphorus oxychloride (POCl). The vessel was cooled to 5°-10° C., and 500 g of dry 2,6-Dihydroxy 5-fluoro-3-cyanopyridine was added in portions at a temperature below 30° C. The mixture was heated at 80°-85° C. for 60 minutes and cooled to room temperature. Phosphorus pentachloride (PCls), 2200 g, was added, in portions, to the mixture. After the addition was complete, the mixture was heated to 100°-104° C. The reaction was stopped after about 30 hours. The mixture was cooled to room temperature, and POCl was removed under reduced pressure. 1,2-Dichloroethane (DCE), 2.0 L, was added to the residue, and the mixture was cooled to 5-10°C. in an ice bath. Distilled water, 5000 mL, was added slowly to the mixture, maintaining the temperature below 40°C. After the water addition, the mixture was stirred at room temperature for an hour. The 1,2-dichloroethane (DCE) layer was separated, and the aqueous layer was extracted with DCE. The DCE extracts were combined. The DCE was removed by vacuum distillation. The residual 2,6- dichloro-5-fluoro-3-cyanopyridine product is used in situ for the next step. 2,6- dichloro-5-fluoro-3-cyanopyridine was placed in a 12 L flask, cooled to 5-10°C. in an ice bath, and added 2300 mL of concentrated sulfuric acid. The residual DCE was then removed under vacuum at room temperature. After removal of the DCE, the mixture was heated at 65°-70° C. for 1–2 hours and monitored by HPLC. After about 2 hours, the mixture was cooled to about 10° C. in an ice bath. The further purity obtained 2,6-Dichloro-5-fluoronicotinamide.

2,6-Dichloro-5-fluoronicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-Dichloro-5-fluoronicotinamide manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,6-DICHLORO-5-FLUORONICOTINAMIDE 113237-20-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Hebei Mingeng Biotechnology Co., Ltd
Product
2,6-Dichloro-5-fluoronicotinamide 113237-20-0
Price
US $150.00/ASSAYS
Min. Order
10g
Purity
>99%
Supply Ability
500kg/month
Release date
2021-12-03
Henan Aochuang Chemical Co.,Ltd.
Product
2,6-DICHLORO-5-FLUORONICOTINAMIDE 113237-20-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

113237-20-0, 2,6-Dichloro-5-fluoronicotinamideRelated Search:

Formamide 2,6-DICHLORO-5-FLUORO-N-ISOPROPYLNICOTINAMIDE 2,6-DICHLORO-N-(4-CHLOROPHENYL)-5-FLUORONICOTINAMIDE N-[4-(TERT-BUTYL)PHENYL]-2,6-DICHLORO-5-FLUORONICOTINAMIDE 2,6-DICHLORO-5-FLUORO-N-PHENYLNICOTINAMIDE 2,6-DICHLORO-5-FLUORONICOTINAMIDE (2,6-DICHLORO-5-FLUOROPYRIDIN-3-YL)(PIPERIDINO)METHANONE (2,6-DICHLORO-5-FLUOROPYRIDIN-3-YL)(MORPHOLINO)METHANONE 2,6-DICHLORO-5-FLUORO-N-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINAMIDE 2,6-DICHLORO-5-FLUORO-N-PYRIDIN-3-YLNICOTINAMIDE 2,6-DICHLORO-5-FLUORO-N-(2-FURYLMETHYL)NICOTINAMIDE 2,6-DICHLORO-5-FLUORO-N-(2-THIENYLMETHYL)NICOTINAMIDE

  • 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE
  • 2,6-DICHLORO-5-FLUORONICOTINAMIDE
  • 2,6-Dichloro-5-fluoronicotinamide 97%
  • CPD2809-A1
  • 2,6-DICHLORO-5-FLUORONICOTIMIDE
  • 2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine
  • 3-PyridinecarboxaMide, 2,6-dichloro-5-fluoro-
  • 2,6-Dichloro-5-fluoronicotinamide97%
  • 2,6-dichloro-3-carboxamide-5-fluoropyridine
  • 2,6-DICHLORO-5-FLUORONICOTINAMIDE ISO 9001：2015 REACH
  • 2,6-Dichloro-3-formamide-5-fluoropyridine
  • Sotorasib Impurity 1
  • Olutasidenib Impurity 32
  • 113237-20-0
  • C6H3Cl2FN2O
  • 113237-20-0