2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE

Product Name: 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE
CAS No.: 111841-05-5
Chemical Name: 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE
Synonyms: 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE;2-Bromo-1-(5-chloro-3-methoxy-phenyl)-ethanone;Ethanone, 2-bromo-1-(5-chloro-2-methoxyphenyl)-;2-Bromo-1-(5-chloro-2-methoxyphenyl)ethan-1-one
CBNumber: CB5740914
Molecular Formula: C9H8BrClO2
Formula Weight: 263.52
MOL File: 111841-05-5.mol

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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Property

Boiling point:: 326.3±32.0 °C(Predicted)
Density: 1.549±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Safety

HS Code: 2914500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B821108
Product name: 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B821108
Product name: 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging: 100mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140834
Product name: 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging: 250mg
Price: $105
Updated: 2021/12/16

Apolloscientific

Product number: OR500012
Product name: 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging: 250mg
Price: $111
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140834
Product name: 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging: 100mg
Price: $53
Updated: 2021/12/16

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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Chemical Properties,Usage,Production

Synthesis

6342-64-9

111841-05-5

1. Methylation: 5-chloro-2-hydroxyacetophenone (17.0 g, 100 mmol), potassium carbonate (15.1 g, 109 mmol) and iodomethane (12.5 mL, 200 mmol) are dissolved in DMF in a sealed container and stirred at room temperature overnight. Upon completion of the reaction, the DMF was evaporated under reduced pressure and the residue was partitioned with water and ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the crude product. Purification by silica gel column chromatography (eluent: ethyl acetate/hexane) afforded 1-(5-chloro-2-methoxyphenyl)ethanone (17.1 g, 93% yield). Mass spectra (electrospray ionization): (M + 1)+ m/z 185.1, 187.1. 2. Bromination Reaction: 1-(5-chloro-2-methoxyphenyl)ethanone (8.5 g, 46.2 mmol) was dissolved in chloroform (40 mL) and slowly added to a preheated ethyl acetate slurry (150 mL) of copper(II) bromide (20.6 g, 92.4 mmol). The reaction mixture was heated to reflux and maintained for about 1 to 3 hours. After cooling, it was filtered and the filtrate was concentrated to give the crude product. Purification by silica gel column chromatography (eluent: dichloromethane) afforded 2-bromo-1-(5-chloro-2-methoxyphenyl)ethanone (12.0 g, 99% yield). MS (electrospray ionization): (M + 1)+ m/z 185.1, 187.1.

References

[1] Patent: WO2005/19184, 2005, A1. Location in patent: Page/Page column 74
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 5, p. 1291 - 1295
[3] Patent: WO2005/19184, 2005, A1. Location in patent: Page/Page column 43-44
[4] Chemical Communications, 2014, vol. 50, # 51, p. 6726 - 6728
[5] Patent: WO2016/16370, 2016, A1. Location in patent: Page/Page column 44

2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Suppliers

China 24 India 1 United Kingdom 1 United States 2 Global 28

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111841-05-5, 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONERelated Search:

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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE

2-Bromo-1-(5-chloro-2-methoxyphenyl)ethan-1-one

Ethanone, 2-bromo-1-(5-chloro-2-methoxyphenyl)-

2-Bromo-1-(5-chloro-3-methoxy-phenyl)-ethanone

111841-05-5

11841-05-5