2-PHTHALIMIDOETHANESULFONYL CHLORIDE
- Product Name
- 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
- CAS No.
- 4403-36-5
- Chemical Name
- 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
- Synonyms
- AKOS MSC-0752;AKOS BBS-00004578;2-Phthalimidoethanesulfonyl chlorid;2-PHTHALIMIDOETHANESULFONYL CHLORIDE;2-Phthalimidoethanesulfonyl chloride - [P3032];2-(1,3-dioxoisoindolin-2-yl)ethane-1-sulfonyl chloride;2H-Isoindole-2-ethanesulfonyl chloride, 1,3-dihydro-1,3-dioxo-;2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONYL CHLORIDE;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethane-1-sulfonyl chloride;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-ethanesulfonyl chloride
- CBNumber
- CB5740934
- Molecular Formula
- C10H8ClNO4S
- Formula Weight
- 273.69
- MOL File
- 4403-36-5.mol
2-PHTHALIMIDOETHANESULFONYL CHLORIDE Property
- Melting point:
- 158-163℃
- Boiling point:
- 416.5±28.0 °C(Predicted)
- Density
- 1.585±0.06 g/cm3(Predicted)
- vapor pressure
- 0-0Pa at 20-50℃
- storage temp.
- 2-8°C
- pka
- -2.47±0.20(Predicted)
- form
- Slurry
- color
- Yellow to orange to brown
- Water Solubility
- Reacts with water.
- Sensitive
- Moisture Sensitive
- Stability:
- Hygroscopic, Moisture Sensitive
- InChIKey
- HCPVYBCAYPMANM-UHFFFAOYSA-N
- LogP
- 1.12-2.44 at 25℃
- CAS DataBase Reference
- 4403-36-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-60
- RIDADR
- 3261
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29251900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 739820
- Product name
- 2-Phthalimidoethanesulfonyl chloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $85.2
- Updated
- 2023/06/20
- Product number
- P2049
- Product name
- 2-Phthalimidoethanesulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- P2049
- Product name
- 2-Phthalimidoethanesulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $224
- Updated
- 2025/07/31
- Product number
- X3062
- Product name
- 2-Phthalimidoethanesulfonyl chloride
- Packaging
- 25g
- Price
- $391
- Updated
- 2021/12/16
- Product number
- FD116717
- Product name
- 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonyl chloride
- Packaging
- 5G
- Price
- $436
- Updated
- 2021/12/16
2-PHTHALIMIDOETHANESULFONYL CHLORIDE Chemical Properties,Usage,Production
Uses
2-(Phthalimido)ethanesulfonyl chloride is an important raw material and intermediate used in pharmaceuticals, agro based and dye stuff fields.
Synthesis
85-44-9
107-35-7
4403-36-5
The general procedure for the synthesis of 2-phenylenedi(meth)iminoethane sulfonyl chloride from phthalic anhydride and taurine is as follows:1. A suspension of taurine (8.0 g, 63.9 mmol) and potassium acetate (6.7 g, 68.3 mmol) was refluxed in acetic acid for 15 min. 2. Phthalic anhydride (10.1 g, 68.4 mmol) was added, and the reaction was continued to be refluxed for 3 h. 3. Upon completion of the reaction, the reaction was cooled to room temperature, the solid product was collected by filtration, washed with cold acetic acid and dried under vacuum at 100 °C to give a white solid.4. The above white solid (14.3 g, 54.7 mmol) was suspended in toluene (50 ml), and phosphorus pentachloride (8.12 g, 39.0 mmol) was added under the protection of nitrogen.5. After the reaction mixture was heated and refluxed for 1 hour The reaction mixture was heated and refluxed for 1 hour, then phosphorus pentachloride (8.12 g, 39.0 mmol) was added again and refluxing was continued for another 2.5 hours.6 Upon completion of the reaction, a brownish solution was poured from a small amount of the solid formed, and the solution was subsequently concentrated under vacuum.7 The concentrated residue was poured into a mixture of ice and water (ice:water=50:50, 100 ml), and the solid product was filtered to collect the solid product.8 Finally, the solid was dried under vacuum at 45°C for 16 hours to obtain a light brown color.9 The reaction was carried out under nitrogen protection. Vacuum dried for 16 hours to give a light brown solid product (6.4 g, 34% yield).
References
[1] Patent: US6313312, 2001, B1
[2] Archiv der Pharmazie, 2007, vol. 340, # 12, p. 656 - 660
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2390 - 2400
[4] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 108 - 122
2-PHTHALIMIDOETHANESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-PHTHALIMIDOETHANESULFONYL CHLORIDE manufacturers
- Product
- 2-PHTHALIMIDOETHANESULFONYL CHLORIDE 4403-36-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02