N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE

Product Name: N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
CAS No.: 113558-89-7
Chemical Name: N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
Synonyms: E-4031;E-4031 (free base);E-4031 DIHYDROCHLORIDE;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide;4'-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL] METHANESULFONANILIDE, 2HCL;Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-;N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
CBNumber: CB5749205
Molecular Formula: C21H27N3O3S
Formula Weight: 401.52
MOL File: 113558-89-7.mol

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N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Property

Boiling point:: 561.7±60.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: RT
solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).
form: White solid.
pka: 7.11±0.10(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324470
Product name: E-4031 - CAS 113558-89-7 - Calbiochem
Purity: A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC?? = 10 nM).
Packaging: 5MG
Price: $391
Updated: 2025/07/31

Tocris

Product number: 1808
Product name: E-4031dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $209
Updated: 2021/12/16

Tocris

Product number: 1808
Product name: E-4031dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $862
Updated: 2021/12/16

Usbiological

Product number: 255211
Product name: E-4031 dihydrochloride
Packaging: 10mg
Price: $466
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015408
Product name: N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $496.02
Updated: 2021/12/16

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N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable.

Uses

E-4031 free base is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

Definition

ChEBI: E-4031 is a sulfonamide.

in vitro

it has been reported that e-4031 could induce eads or tdp, and such induction correlated with a significant increase in variability of repolarization. in addition, e-4031 at 0.1 um was able to significantly prolong cycle length, action potential duration, and depolarized maximum diastolic potential. e-4031could also reduce the upstroke velocity of the action potential as well as the diastolic depolarization rate [1].

in vivo

animal study showed that e-4031 at 0.01 and 0.1 mg/kg could provide effective in-vitro plasma concentrations to significantly inhibit ikr and thus delayed the repolarization beyond the initiation of diastole, leading to the inversion of electro-mechanical coupling, which provides an ideal proarrhythmic substrate [2]. another sutdy found that e-4031 could prolong qt interval and ari in all lv layers, though the magnitude of prolongation was greatest in mid, particularly during bradycardia [3].

IC 50

7.7 nm for herg

References

[1] E. FICKER. The Binding Site for Channel Blockers That Rescue Misprocessed Human Long QT Syndrome Type 2 ether-a-gogo-related Gene (HERG) Mutations*[J]. The Journal of Biological Chemistry, 2002, 122 1: 4989-4998. DOI:10.1074/jbc.m107345200
[2] E WETTWER. Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.[J]. Journal of Cardiovascular Pharmacology, 1991, 17 3: 480-487. DOI:10.1097/00005344-199103000-00018

N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Suppliers

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113558-89-7, N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDERelated Search:

Glibenclamide Nicorandil CHARYBDOTOXIN TRAM-34 5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE 4-BENZOYLPIPERIDINE HYDROCHLORIDE N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE Betahistine dihydrochloride 2-(2'-AMINOETHYL)-6-METHYLPYRIDINE N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE E-4031 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE

E-4031

E-4031 DIHYDROCHLORIDE

N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE

E-4031 (free base)

N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide

4'-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL] METHANESULFONANILIDE, 2HCL

Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-

113558-89-7