2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL
- Product Name
- 2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL
- CAS No.
- 30201-72-0
- Chemical Name
- 2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL
- Synonyms
- ASINEX-REAG BAS 02768131;2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL;2-Amino-5-ethyl-6-hydroxypyrimidin-4(3H)-one;4(3H)-Pyrimidinone, 2-amino-5-ethyl-6-hydroxy-
- CBNumber
- CB5750386
- Molecular Formula
- C6H9N3O2
- Formula Weight
- 155.15
- MOL File
- Mol file
2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL Property
- Melting point:
- 320 °C
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.92±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9517AD
- Product name
- 2-Amino-5-ethyl-pyrimidine-4,6-diol
- Packaging
- 1g
- Price
- $354
- Updated
- 2021/12/16
- Product number
- 018544
- Product name
- 2-Amino-5-ethyl-pyrimidine-4,6-diol
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- NUC0001250
- Product name
- 2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $672
- Updated
- 2021/12/16
- Product number
- 9517AD
- Product name
- 2-Amino-5-ethyl-pyrimidine-4,6-diol
- Packaging
- 5g
- Price
- $901
- Updated
- 2021/12/16
- Product number
- A105165
- Product name
- 2-Amino-5-ethyl-6-hydroxypyrimidin-4(3H)-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL Chemical Properties,Usage,Production
Synthesis
50-01-1
133-13-1
30201-72-0
GENERAL METHOD: Sodium metal (12.9 g, 0.56 mol) was dissolved in anhydrous ethanol (300 mL) under argon protection while stirring vigorously using a mechanical stirrer. The reaction flask was equipped with a reflux condenser with a calcium chloride drying tube. After all the sodium was completely dissolved, the reaction mixture was cooled to room temperature. Guanidine hydrochloride (21.02 g, 0.22 mol) and monosubstituted diethyl malonate (0.2 mol) were added sequentially under continuous vigorous stirring. Stirring became difficult after 2 h of continued vigorous stirring due to the large amount of solid products produced during the reaction. Subsequently, anhydrous ethanol (200 mL) was added and the reaction mixture was refluxed for 1 hour while stirring was maintained. Upon completion of the reaction, a portion of the ethanol (about 200-300 mL) was evaporated under reduced pressure using a rotary evaporator, and then water (500 mL) was added to the reaction mixture. After stirring, the product was almost completely dissolved in the form of sodium salt. Next, the reaction mixture was neutralized by dropwise addition of acetic acid, resulting in immediate quantitative precipitation of the target product 2-amino-5-ethyl-6-hydroxypyrimidin-4(3H)-one as a fine solid. The mixture was heated under reflux conditions for 10 minutes and then cooled to room temperature. This heating and cooling process was repeated twice to obtain a solid product that could be easily filtered. The solid was collected by filtration and washed sequentially with water (2 x 50 mL), ethanol (2 x 50 mL) and acetone (2 x 50 mL). Finally, the product was dried under high vacuum at 60 °C for 2 days. The resulting product was pure enough to be used in subsequent reactions and was analyzed to contain only water of crystallization.
References
[1] Medicinal Chemistry Research, 2014, vol. 23, # 10, p. 4482 - 4490
[2] Medicinal Chemistry Research, 2014, vol. 23, # 10, p. 4482 - 4490
2-AMINO-5-ETHYL-PYRIMIDINE-4,6-DIOL Preparation Products And Raw materials
Raw materials
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