(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID
- Product Name
- (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID
- CAS No.
- 147266-79-3
- Chemical Name
- (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID
- Synonyms
- (4S)-Boc-4-phenoxy-L-Proline;(2S,4S)-Boc-4-phenoxy-Pro-OH;(4S)-N-Boc-4-phenoxy-L-proline;(2S,4S)-BOC-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID;(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXYPYRROLIDINE-2-CARBOXYLIC ACID;(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID;1,2-Pyrrolidinedicarboxylic acid, 4-phenoxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
- CBNumber
- CB5750553
- Molecular Formula
- C16H21NO5
- Formula Weight
- 307.34
- MOL File
- 147266-79-3.mol
(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID Property
- Boiling point:
- 455.8±45.0 °C(Predicted)
- Density
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.66±0.40(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- -11.2°(C=0.01g/mL, ETOH, 20°C, 589nm)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4500AD
- Product name
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-phenoxy-2-pyrrolidinecarboxylicacid
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- BAA3450
- Product name
- Boc-L-Pro(4-OPh)-OH(2S,4S)
- Packaging
- 1g
- Price
- $202.5
- Updated
- 2021/12/16
- Product number
- 023520
- Product name
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-phenoxy-2-pyrrolidinecarboxylic acid
- Packaging
- 500mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- FB56815
- Product name
- (2S,4S)-Boc-4-phenoxy-pyrrolidine-2-carboxylic acid
- Packaging
- 1g
- Price
- $241.7
- Updated
- 2021/12/16
- Product number
- FB56815
- Product name
- (2S,4S)-Boc-4-phenoxy-pyrrolidine-2-carboxylic acid
- Packaging
- 2g
- Price
- $386.7
- Updated
- 2021/12/16
(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
93967-75-0
147266-79-3
General procedure for the synthesis of (2S,4S)-BOC-4-phenoxypyrrolidine-2-carboxylic acid from methyl (2S,4S)-1-BOC-4-phenoxypyrrolidine-2-carboxylate: Step 2: Synthesis of (2S,4S)-1-tert-butoxycarbonyl-4-phenoxy-2-pyrrolidine carboxylic acid Methyl (2S,4S)-1-tert-butoxycarbonyl-4-phenoxy-2-pyrrolidinylcarboxylate (4.31 g, 16.5 mmol) was dissolved in THF (132 ml), followed by addition of 0.25N NaOH solution (132 ml, 33.0 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue obtained was acidified with 1N HCl and subsequently extracted with chloroform. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After removing the solvent by distillation under reduced pressure, the crude product obtained was recrystallized with hexane-chloroform mixed solvent to give (2S,4S)-BOC-4-phenoxypyrrolidine-2-carboxylic acid (2.96 g, 58% yield) as a final white crystalline powder. 1H-NMR (DMSO-d6) δ: 1.36 (s, 9H), 2.16 (d, J = 13.2 Hz, 1H), 2.56 (m, 1H), 3.46 (m, 1H), 3.71 (dt, J = 12.0, 5.4 Hz, 1H), 4.26 (dt, J = 9.5, 7.1 Hz, 1H), 4.99 (m, 1H). 6.85 (m, 2H), 6.94 (t, J = 7.3 Hz, 1H), 7.28 (t, J = 7.3 Hz, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 8, p. 2725 - 2746
[2] Patent: EP1346982, 2003, A1
(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID manufacturers
- Product
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-phenoxy-2-pyrrolidinecarboxylic acid 147266-79-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08