H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- Product Name
- H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- CAS No.
- 374675-18-0
- Chemical Name
- H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- Synonyms
- KISSPEPTIN-13;KISSPEPTIN-13 (HUMAN);Kisspeptin-13 acetate;METASTIN (42-54) (HUMAN);KISS-1 (109-121) (HUMAN);Kisspeptin-13 374675-18-0;KISSPEPTIN-14 (2-14) (HUMAN);KISSPEPTIN-54 (42-54) (HUMAN);LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2;H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- CBNumber
- CB5750674
- Molecular Formula
- C78H107N21O18
- Formula Weight
- 1626.81
- MOL File
- 374675-18-0.mol
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Property
- Sequence
- Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
N-Bromosuccinimide Price
- Product number
- orb372482
- Product name
- Kisspeptin-13
- Purity
- > 95%
- Packaging
- 1mg
- Price
- $307.7
- Updated
- 2021/12/16
- Product number
- BRS0000520
- Product name
- KISSPEPTIN-13
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.68
- Updated
- 2021/12/16
- Product number
- orb372482
- Product name
- Kisspeptin-13
- Purity
- > 95%
- Packaging
- 5mg
- Price
- $596.7
- Updated
- 2021/12/16
- Product number
- orb372482
- Product name
- Kisspeptin-13
- Purity
- > 95%
- Packaging
- 10mg
- Price
- $765
- Updated
- 2021/12/16
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Chemical Properties,Usage,Production
Uses
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research[1][2][3][4].
in vivo
Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor[1].
| Animal Model: | Male Swiss mice with memory impairment induced by A-beta[1] |
| Dosage: | 2 μg/side |
| Administration: | Intracerebroventricular administration; 2 μg/side; once |
| Result: | Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54. |
References
[1] Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95. DOI:10.1016/j.nlm.2015.05.010
[2] Silvestre RA, et al., Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol. 2008 Feb;196(2):283-90. DOI:10.1677/JOE-07-0454
[3] Csabafi K, et al., Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in rats. Behav Brain Res. 2013 Mar 15;241:56-61. DOI:10.1016/j.bbr.2012.11.039
[4] Tanaka M, et al., Neurotransmissions of antidepressant-like effects of kisspeptin-13. Regul Pept. 2013 Jan 10;180:1-4. DOI:10.1016/j.regpep.2012.08.017
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
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