RESISTOMYCIN
- Product Name
- RESISTOMYCIN
- CAS No.
- 20004-62-0
- Chemical Name
- RESISTOMYCIN
- Synonyms
- X 340;A 3733A;Itamycin;Geliomycin;Croceomycin;Brn 2187224;RESISTOMYCIN;Antibiotic A 3733a;CroceoMycin, GelioMycin, HelioMycin, ItaMycin, 11-98, A 3733A, X 340;3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-2H-benzo[cd]pyrene-2,6(1H)-dione
- CBNumber
- CB5755785
- Molecular Formula
- C22H16O6
- Formula Weight
- 376.36
- MOL File
- 20004-62-0.mol
RESISTOMYCIN Property
- Melting point:
- 325℃ (decomposition)
- Boiling point:
- 424.93°C (rough estimate)
- Density
- 1.2465 (rough estimate)
- refractive index
- 1.4450 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO;dimethyl formamide
- form
- powder
- pka
- 4.25±0.40(Predicted)
Safety
- HS Code
- 29419000
- Toxicity
- mouse,LD50,intraperitoneal,20mg/kg (20mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 3, Pg. 351, 1980.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20685
- Product name
- Resistomycin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 20685
- Product name
- Resistomycin
- Packaging
- 5mg
- Price
- $635
- Updated
- 2024/03/01
- Product number
- R144683
- Product name
- Resistomycin
- Packaging
- 2.5mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 207382
- Product name
- Resistomycin
- Packaging
- 1mg
- Price
- $329
- Updated
- 2021/12/16
- Product number
- R1589
- Product name
- Resistomycin
- Packaging
- 1mg
- Price
- $368
- Updated
- 2021/12/16
RESISTOMYCIN Chemical Properties,Usage,Production
Uses
Resistomycin is an antibiotic RNA polymerase inhibitor and apoptosis inducer.
Uses
Resistomycin is a tetrahydroxyantrone has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
Uses
Resistomycin is a tetrahydroxyanthrone that has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
Definition
ChEBI: Resistomycin is a phenanthrol.
Biological Activity
resistomycin is a natural antibiotic.resistomycin is a natural antibiotic produced by several actinobacteriae, such as streptomyces.
in vitro
resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of hypericum perforatum l. as modulators for apoptosis. in human megakaryoblastic leukemia cmk-7 cells, resistomycin could inhibit apoptosis induced by actinomycin d (ad) with or without acceleration by colcemid (cl), ic50 for inhibition against ad-induced apoptosis was about 0.5 μm and ic50 for inhibition against ad plus cl-induced apoptosis was about 1 μm. cl alone induced weak apoptosis in cells, which could be enhanced by resistomycin. moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. in addition, pkc in cmk-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
References
[1] shiono, y. ,shiono, n.,seo, s., et al. effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia cmk-7 cell line. z. naturforsch. c. 57(9-10), 923-929 (2002).
RESISTOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
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