ChemicalBook > CAS DataBase List > Gamma oryzanol

Gamma oryzanol

Product Name
Gamma oryzanol
CAS No.
11042-64-1
Chemical Name
Gamma oryzanol
Synonyms
GAMMA-ORYZANOL;oz;Gu Weisu;gammariza;Γ-ORYZANOL;.gamma.-Orizanol;hi-z;oliver;Caclate;gamma-oz
CBNumber
CB5758140
Molecular Formula
C40H58O4
Formula Weight
602.89
MOL File
11042-64-1.mol
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Gamma oryzanol Property

Melting point:
135-137°C
Boiling point:
571.92°C (rough estimate)
Density 
0.9751 (rough estimate)
refractive index 
1.4760 (estimate)
storage temp. 
Sealed in dry,Room Temperature
Water Solubility 
Practically insoluble in water
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
powder to crystaline
color 
White to Light yellow
Odor
little or no odor
Merck 
14,6886
InChIKey
FODTZLFLDFKIQH-PGYKLSNGNA-N
SMILES
C123CC[C@]4(C)[C@H](CC[C@@]4(C)C1CCC1C(C)(C)[C@@H](OC(=O)/C=C/C4=CC=C(O)C(OC)=C4)CC[C@]21C3)C(C)CC/C=C(\C)/C |&1:3,5,8,17,34,r|
LogP
13.205 (est)
CAS DataBase Reference
11042-64-1(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1/PG II
RTECS 
RN0050000
HS Code 
3822.19.0080
HazardClass 
6.1
PackingGroup 
II
Toxicity
LD50 oral in rat: > 25gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1479202
Product name
Gamma-Oryzanol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50MG
Price
$410
Updated
2025/07/31
TCI Chemical
Product number
O0172
Product name
γ-Oryzanol
Packaging
25g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
O0172
Product name
γ-Oryzanol
Packaging
250g
Price
$257
Updated
2025/07/31
TRC
Product number
O675500
Product name
γ-Oryzanol
Packaging
250g
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-7898
Product name
γ-Oryzanol
Packaging
500mg
Price
$50
Updated
2021/12/16
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Gamma oryzanol Chemical Properties,Usage,Production

Description

Gamma oryzanol is a lipid fraction derived from rice-bran oil. Oryzanol was first isolated from rice-bran oil in the 1950s. Several lipid fractions were isolated from the oil.The third (gamma) fraction isolated was oryzanol.It is made up of a mixture of ferulic acid esters and plant sterols. Similar in structure to cholesterol, the phytosterols and triterpenes that comprise oryzanol include campesterol, stigmasterol, beta sitosterol, cycloartanol, and cycloartenol. Because phytosterols are poorly absorbed, it has been suggested that they may reduce blood cholesterol by inhibiting intestinal cholesterol absorption.In contrast, the ferulic acid portion of gamma oryzanol is easily absorbed into the body's tissues. Ferulic acid also has demonstrated antioxidant properties in vitro.

Chemical Properties

White to Off-White Solid

Occurrence

Gamma oryzanol is found in rice-bran oil, which is commercially available in Japan for use in salad oils and frying.Crude rice-bran oil contains approximately 1.56% oryzanol.Of the 180 mg of plant sterols found in the typical American diet，about 4% is gamma-oryzanol.One cup of brown rice provides 18 mg gamma oryzanol, whereas white rice provides 4mg. The ferulic acid portion of gamma oryzanol is naturally found in the bran of cereals, and in fruits and vegetables.Ferulic acid is also a metabolite of caffeic acid found in coffee.

Uses

Gamma Oryzanol is a mixture of 6 substances derived from rice bran oil, including sterols and ferulic acid, called Cycloartanyl Ferulate or Triterpene alcohol ferulate. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol. gamma oryzanol is widely used as a food additive, pharmaceutical material. In cosmetic area, the application to creams and sunscreens exploiting its skin age resistor function and ultraviolet absorbing effect.

Preparation

Extraction of gamma oryzanol from processes oil.
Gamma oryzanol can be extracted by liquid-liquid extraction method by using organic solvent or by using supercritical extraction method. The following procedure was followed to extract gamma oryzanol from the oil.
Rice Bran Oil (1 kg)→NaOH and water was added→Stirred and stored for one day at room temperature→Acidified to pH 4 using H2SO4→Heated to 80°C→50g NaCl was added→Oily layer was obtained→ Methanol was added→ Mixture was cooled to 0°C for 2 hrs.→ Waxy component precipitated→ Solution of 5g H2SO4 in 300 ml methanol→ Stored for one day→ Stirred at 40°C to remove/evaporate methanol→ To 100g residue 100g n-hexane was added→ Solvent Distillation→ Treatment of 100 ml methanol was given→ Residue was extracted 3 times with 50ml 0.5N→ methanolicNaOH→ Neutralised with methanolic acetic acid to pH 6.8-7→ Stored to precipitate gamma oryzanol.
The yield of gamma oryzanol was found to be 2.2%

Definition

ChEBI: Gamma-Oryzanol (TN) is a triterpenoid.

General Description

Gamma oryzanol is found in the by-products of the rice industry, such as rice bran and rice bran oil. It exhibits a wide range of biological activities, including anticarcinogenic, anti-inflammatory, antihyperlipidemic, and neuroprotective properties, which are primarily due to its high antioxidant capacity.

Side effects

Gamma oryzanol has no side effects for horses, dogs or humans.
Toxicity studies on animals demonstrate that gamma oryzanol is a very safe compound. No significant side-effects have been reported in human trials at the above noted recommended dosage.
Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.

Safety Profile

A poison by skin contact. Moderately toxic by intravenous route. Low toxicity by ingestion. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.

Dosage

A typical dosage of gamma oryzanol is 500 mg daily.

Gamma oryzanol Preparation Products And Raw materials

Raw materials

Preparation Products

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Gamma oryzanol Suppliers

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View Lastest Price from Gamma oryzanol manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
γ-Oryzanol 11042-64-1
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-11-04
Wuhan JiyunZen Tech Co., Ltd.
Product
Gamma-Oryzanol 11042-64-1
Price
US $5.00-0.50/KG
Min. Order
0.10000000149011612KG
Purity
99% hplc
Supply Ability
5000kg
Release date
2025-06-06
Wuhan JiyunZen Tech Co., Ltd.
Product
gamma-Oryzanol 11042-64-1
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-08

11042-64-1, Gamma oryzanolRelated Search:

Nicotinic acid COD LIVER OIL ORYZANOL 4-Aminobutyric acid Isobutyl cinnamate Ethyl 4-hydroxy-3-methoxycinnamate 4-tert-Butylcyclohexyl acetate CYCLOHEXYL CINNAMATE Pentyl cinnamate CYCLOARTENYL FERULATE Isopropyl ferulate HEPTYL CINNAMATE N-NONYL ACRYLATE OCTYL CINNAMATE 4-TERT-BUTYLCYCLOHEXYL ACRYLATE Gamma oryzanol SPIRO[2.5]OCTANE

  • GAMMA-ORYZANOL
  • .gamma.-Orizanol
  • gamma-orizanol
  • gamma-oz
  • gammariza
  • Major coMpounds: Cycloartenylferulate and 24-Methylen Cycloartanylferulate
  • Other coMpounds: CaMpesterylferulate, CaMpestanylferulate, β-Sitosterylferulate and Cycloartanylferulate
  • Gu Weisu
  • gamma.-Orizanol Oryzanol
  • ORYZANOLUM
  • Γ-ORYZANOL
  • hi-z
  • oliver
  • oz
  • GAMMAORYZANOL,98%(BULK
  • GAMMA-ORYZANOL,CRYSTALLINEPOWDER
  • AMMA-ORYZANOL
  • Gamma Oryzanol (Rice Bran) Extract
  • Caclate
  • Gammajust 50
  • g-Oryzanol
  • Oryzanol, MIN. 20 MESH
  • γ-oryzanol γ-Oryzanol
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  • γ-Oryzanol
  • 11042-64-1
  • 11042-61-1
  • 1042-64-1
  • C40H58O4
  • Plant extracts
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Nutritional Supplements
  • Aromatic Esters