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NF449

Product Name
NF449
CAS No.
389142-38-5
Chemical Name
NF449
Synonyms
NF449;NF449 OCTASODIUM SALT;NF449 - CAS 389142-38-5 - Calbiochem;1,3-Benzenedisulfonic acid, 4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakis-;4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-1,3-benzenedisulfonicacid,octasodium;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYLIMINO)]]TETRAKIS-(BENZENE-1,3-DISULFONIC ACID, 8NA);4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt;4,4',4'',4'''-[CARBONYLBIS(IMINO-5,1,3-BENZENETRIYL-BIS(CARBONYLIMINO))]TETRAKIS-1,3-BENZENEDISULFONIC ACID, OCTASODIUM SALT;4,4μ,4,4μ-[Carbonylbis[imino-5,1,3-benzenetriyl bis(carbonyl-imino)]]tetrakis(benzene-1,3-disulfonic acid) octasodium salt;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYL-IMINO)]]TETRAKIS(BENZENE-1,3-DISULFONIC ACID) OCTASODIUM SALT
CBNumber
CB5764453
Molecular Formula
C41H32N6O29S8
Formula Weight
1329.24
MOL File
389142-38-5.mol
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NF449 Property

Melting point:
>300°C
Density 
1.991±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
pka
-2.03±0.50(Predicted)
color 
white
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
480420
Product name
NF449
Packaging
10mg
Price
$227.55
Updated
2021/12/16
Tocris
Product number
1391
Product name
NF449
Packaging
10
Price
$236
Updated
2021/12/16
Tocris
Product number
1391
Product name
NF449
Packaging
50
Price
$992
Updated
2021/12/16
Usbiological
Product number
165610
Product name
NF449
Packaging
10mg
Price
$403
Updated
2021/12/16
Usbiological
Product number
255975
Product name
NF 449
Packaging
10mg
Price
$489
Updated
2021/12/16
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NF449 Chemical Properties,Usage,Production

Uses

NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism.

Biological Activity

Potent purinergic receptor antagonist that displays high selectivity for P2X 1 (IC 50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X 1 , rP2X 1+5 , rP2X 2+3 , rP2X 3 , rP2X 2 and P2X 4 receptors respectively). Provides antithrombotic protection in vivo . Also acts as a G s α -selective antagonist.

in vivo

At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor[3].

IC 50

p2x1 Receptor

NF449 Preparation Products And Raw materials

Raw materials

Preparation Products

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NF449 Suppliers

China 35 Germany 3 Switzerland 1 United Kingdom 2 United States 6 Global 47
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Guangzhou Bingheng Biotechnology Co., Ltd.
Tel
13631342304
Country
CHINA
ProdList
188
Advantage
58

389142-38-5, NF449Related Search:

sodium N-benzylsulphanilate NF110 4-ACETAMIDOBENZENESULFINIC ACID SODIUM SALT NF449 4-Amino-1,3-benzenedisulfonic acid

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  • 4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYL-IMINO)]]TETRAKIS(BENZENE-1,3-DISULFONIC ACID) OCTASODIUM SALT
  • 4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYLIMINO)]]TETRAKIS-(BENZENE-1,3-DISULFONIC ACID, 8NA)
  • NF449
  • NF449 OCTASODIUM SALT
  • 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-1,3-benzenedisulfonicacid,octasodium
  • 4,4μ,4,4μ-[Carbonylbis[imino-5,1,3-benzenetriyl bis(carbonyl-imino)]]tetrakis(benzene-1,3-disulfonic acid) octasodium salt
  • NF449 - CAS 389142-38-5 - Calbiochem
  • 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt
  • 1,3-Benzenedisulfonic acid, 4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakis-
  • 389142-38-5
  • C41H24N6Na8O29S8
  • Purinergics P2 receptor