4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
- Product Name
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
- CAS No.
- 84449-80-9
- Chemical Name
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
- Synonyms
- Einecs 282-882-9;4-[2-(1-Pipiridine)e;Raloxifene Impurity 6;Raloxifene side chain;Raloxifene Benzoic Acid Impurity;Raloxifene Impurity(Hydrochloride）;4-[2-(1-piperidyl) ethoxy] benzoate;4-(2-PIPERIDINOETHOXY)BENZOIC ACID HCL;4-[2-(1-Pipiridine)Ethody]BenzoicAcidHcl;4-{2-(1-Piperidino)ethoxy}benzoic acid HCl
- CBNumber
- CB5774865
- Molecular Formula
- C14H20ClNO3
- Formula Weight
- 285.77
- MOL File
- 84449-80-9.mol
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride Property
- Melting point:
- 267-271°C dec.
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- InChI
- InChI=1S/C14H19NO3.ClH/c16-14(17)12-4-6-13(7-5-12)18-11-10-15-8-2-1-3-9-15;/h4-7H,1-3,8-11H2,(H,16,17);1H
- InChIKey
- CMVTYSMYHSVDIU-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(OCCN2CCCCC2)C=C1.[H]Cl
- CAS DataBase Reference
- 84449-80-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- P482025
- Product name
- 4-[2-(1-Piperidinyl)ethoxy]benzoicAcidHydrochlorideSalt
- Packaging
- 25mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- P482025
- Product name
- 4-[2-(1-Piperidinyl)ethoxy]benzoicAcidHydrochlorideSalt
- Packaging
- 25g
- Price
- $2475
- Updated
- 2021/12/16
- Product number
- A789
- Product name
- 4-[2-(1-Pipiridine)ethoxybenzoicacidhydrochloride
- Packaging
- 25g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- 072952
- Product name
- 4-(2-(Piperidin-1-yl)ethoxy)-benzoic acid hydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 072952
- Product name
- 4-(2-(Piperidin-1-yl)ethoxy)-benzoic acid hydrochloride
- Purity
- 95+%
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
An intermediate in the synthesis of Raloxifene hydrochloride.
Synthesis
93148-78-8
2008-75-5
99-76-3
84449-80-9
Example 4 Preparation of 4-[2-piperidine-1-ethoxy]benzoic acid hydrochloride A mechanical stirrer, condenser tube and a heating unit comprising a heating jacket connected via a temperature controller and an RTD temperature probe were assembled in a 250 mL three-neck flask and operated under nitrogen protection. 7.61 g of methyl 4-hydroxybenzoate (nipagin methyl ester), 11.05 g of 1-(2-chloroethyl)piperidine hydrochloride, 16.59 g of powdered potassium carbonate and 60 mL of isopropyl acetate were added sequentially. The reaction mixture was slowly heated to 80 °C and after 5 hours of reaction, high performance liquid chromatography (HPLC) analysis showed that the reaction was 90% complete. The reaction was continued at 80 °C overnight to ensure complete reaction. Upon completion of the reaction, the mixture was cooled to room temperature, 60 mL of deionized water was added and stirred until all solids were dissolved. The aqueous layer was separated and discarded. The organic layer was extracted three times with 20 mL of 4N hydrochloric acid solution. The extracts containing ethyl 4-[2-piperidin-1-ethoxy]benzoate were combined and heated to reflux (92°C for about 30 minutes to reach reflux). After refluxing for 7.5 hours, about 10 mL of water was removed by distillation, followed by cooling the mixture in an ice bath for 15 minutes. The precipitated 4-[2-piperidine-1-ethoxy]benzoic acid hydrochloride crystals were collected by filtration, washed with acetone and dried. A final product of 12.53 g was obtained in 87.7% yield of the theoretical value.
References
[1] Patent: US5631369, 1997, A
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride manufacturers
- Product
- 4-(2-(piperidin-1-yl)ethoxy)benzoic acid hydrochloride 84449-80-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-26
- Product
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride 84449-80-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 50kg; 500kg
- Release date
- 2019-12-24