2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO-
- Product Name
- 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO-
- CAS No.
- 40026-24-2
- Chemical Name
- 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO-
- Synonyms
- 6-Chlorochroman-2-carboxylic acid;6-chlorochromane-2-carboxylic acid;2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO-;(+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid
- CBNumber
- CB5787728
- Molecular Formula
- C10H9ClO3
- Formula Weight
- 212.63
- MOL File
- 40026-24-2.mol
2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO- Property
- Boiling point:
- 394.7±42.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.01±0.20(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8470DA
- Product name
- 6-Chlorochroman-2-carboxylicacid
- Packaging
- 100mg
- Price
- $234
- Updated
- 2021/12/16
- Product number
- 8470DA
- Product name
- 6-Chlorochroman-2-carboxylicacid
- Packaging
- 250mg
- Price
- $402
- Updated
- 2021/12/16
- Product number
- HCH0350995
- Product name
- 6-CHLORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.23
- Updated
- 2021/12/16
- Product number
- H-3794
- Product name
- 6-Chlorochroman-2-carboxylicacid
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $293.33
- Updated
- 2021/12/16
- Product number
- A221855
- Product name
- 6-Chlorochroman-2-carboxylicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO- Chemical Properties,Usage,Production
Synthesis
52011-76-4
40026-24-2
c) Synthesis of (R,S)-6-chloro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (9c): triethylsilane (2.4 mL, 12.5 mmol) was added slowly and dropwise to a suspension of trifluoroacetic acid (5 mL) of compound 9b (1.13 g, 5 mmol) under stirring. The reaction mixture was stirred continuously at 55°C for three days. Upon completion of the reaction, it was cooled to 25°C and the excess triethylsilane and solvent were removed by distillation under reduced pressure. The residue was dissolved in 1N sodium hydroxide solution and the resulting aqueous solution was washed with ether. Subsequently, the aqueous solution was acidified to pH ~1 with 6N hydrochloric acid and extracted with ethyl acetate. The organic extracts were combined, washed sequentially with water and saturated brine, and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and finally dried under vacuum to give 0.95 g (90% yield) of the title compound 6-chloro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid.1H NMR (300 MHz, DMSO-d6) δ 13.08 (br s, 1H), 7.15 (m, 2H), 6.86 (d, 1H), 4.83 (t , 1H), 2.82 (m, 1H), 2.76 (m, 1H), 2.11 (m, 2H).
References
[1] Tetrahedron: Asymmetry, 1995, vol. 6, # 4, p. 1001 - 1012
[2] Patent: US2005/54630, 2005, A1. Location in patent: Page/Page column 36
2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-CHLORO-3,4-DIHYDRO- manufacturers
- Product
- 6-Chlorochroman-2-carboxylic acid 40026-24-2
- Price
- US $1.00-100.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 300KG
- Release date
- 2024-08-16