ChemicalBook > CAS DataBase List > 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
- Product Name
- 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
- CAS No.
- 114744-50-2
- Chemical Name
- 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
- Synonyms
- 5-bromo-1,2,3,4-tetrahydroquinoline;Quinoline, 5-bromo-1,2,3,4-tetrahydro-;5-bromo-1,2,3,4-tetrahydroquinoline HCl;5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE1HCL SALT;5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
- CBNumber
- CB5802137
- Molecular Formula
- C9H10BrN
- Formula Weight
- 212.09
- MOL File
- 114744-50-2.mol
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5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Property
- Boiling point:
- 300℃
- Density
- 1.428
- Flash point:
- 135℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 4.19±0.20(Predicted)
- Appearance
- Light yellow to brown Liquid
- InChI
- InChI=1S/C9H10BrN/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1,4-5,11H,2-3,6H2
- InChIKey
- WTZQIKXLRRDMCP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2)CCC1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
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N-Bromosuccinimide Price
TRC
- Product number
- B415723
- Product name
- 5-Bromo-1,2,3,4-tetrahydroquinoline
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB71823
- Product name
- 5-Bromo-1,2,3,4-tetrahydroquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB71823
- Product name
- 5-Bromo-1,2,3,4-tetrahydroquinoline
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS32232-A
- Product name
- 5-Bromo-1,2,3,4-tetrahydroquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB71823
- Product name
- 5-Bromo-1,2,3,4-tetrahydroquinoline
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
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5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
15115-60-3
114744-50-2
General procedure for the synthesis of 5-bromo-1,2,3,4-tetrahydroquinoline from 4-bromoinden-1-one: 4-bromoinden-1-one (1.05 g, 5 mmol) was dissolved in methanol (14 ml), hydroxylamine hydrochloride (1.4 g, 20 mmol) was added, and the reaction was carried out at reflux for 1 hour. After completion of the reaction, vacuum concentration was carried out followed by addition of dichloromethane and 50% sodium bicarbonate solution and stirring for 20 min. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated to give a white solid in 99% yield. The white solid (5 mmol) obtained above was dissolved in dichloromethane (30 ml), cooled to 0 °C and diisobutylaluminum hydride (20 ml, 30 mmol, 1.5 M toluene solution) was added slowly. The reaction mixture was stirred at 0°C for 30 min, then moved to room temperature and continued stirring overnight. After completion of the reaction, the reaction was quenched with water under ice bath conditions, extracted with dichloromethane, the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After concentration, it was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) to give 600 mg of 5-bromo-1,2,3,4-tetrahydroquinoline as a pale yellow solid in 56.6% yield.
References
[1] Patent: CN107814785, 2018, A. Location in patent: Paragraph 0062; 0081; 0082; 0083
5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE manufacturers
Career Henan Chemical Co
- Product
- 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 114744-50-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-11
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