Estrogen receptor antagonist 2

Product Name: Estrogen receptor antagonist 2
CAS No.: 2222844-89-3
Chemical Name: Estrogen receptor antagonist 2
Synonyms: AZD-9833;Camizestrant;Camizestrant (AZD-9833);Camizestrant, 10 mM in DMSO;Estrogen receptor antagonist 2;N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine;N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine;3-Pyridinamine, N-[1-(3-fluoropropyl)-3-azetidinyl]-6-[(6S,8R)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-
CBNumber: CB58054396
Molecular Formula: C24H28F4N6
Formula Weight: 476.51
MOL File: 2222844-89-3.mol

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Estrogen receptor antagonist 2 Property

Boiling point:: 590.2±50.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
pka: 14.25±0.60(Predicted)
form: Solid
color: Off-white to light yellow
InChIKey: WDHOIABIERMLGY-CMJOXMDJSA-N
SMILES: C1=NC([C@@H]2C3=C(C4C=NNC=4C=C3)C[C@@H](C)N2CC(F)(F)F)=CC=C1NC1CN(CCCF)C1

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Hazard and Precautionary Statements (GHS)

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Estrogen receptor antagonist 2 Chemical Properties,Usage,Production

Uses

Camizestrant (AZD-9833) is a potent and orally active estrogen receptor (ER) antagonist. Camizestrant is used for the study of ER+ HER2-advanced breast cancer[1].

in vivo

Camizestrant (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft^[1]. Camizestrant (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice^[1].

Animal Model:	Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice^[1]
Dosage:	0.8 mg/kg, 3 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration:	Oral administration; 30 days; once daily
Result:	Inhibited tumor growth in a dose-dependent manner.

References

[1] Bernard Christophe Barlaam, etal. Chemical compounds. Patent US20180111931.

Estrogen receptor antagonist 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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2222844-89-3, Estrogen receptor antagonist 2Related Search:

Estrogen receptor antagonist 2

AZD-9833

Camizestrant

N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine

N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine

3-Pyridinamine, N-[1-(3-fluoropropyl)-3-azetidinyl]-6-[(6S,8R)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-

Camizestrant (AZD-9833)

Camizestrant, 10 mM in DMSO

2222844-89-3