GOT1 inhibitor 2c

Product Name: GOT1 inhibitor 2c
CAS No.: 732973-87-4
Chemical Name: GOT1 inhibitor 2c
Synonyms: GOT1 inhibitor-1;GOT1 inhibitor 2c;GOT1 inhibitor-1, 10 mM in DMSO;N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)-;GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
CBNumber: CB58059447
Molecular Formula: C19H19ClN4O
Formula Weight: 354.83
MOL File: 732973-87-4.mol

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GOT1 inhibitor 2c Property

Boiling point:: 639.5±55.0 °C(Predicted)
Density: 1.387±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (352.28 mM)
pka: 13.07±0.70(Predicted)
form: Solid
color: Off-white to light yellow
Water Solubility: Water: < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

CSNpharm

Product number: CSN27598
Product name: GOT1inhibitor2c
Packaging: 1mg
Price: $65
Updated: 2021/12/16

CSNpharm

Product number: CSN27598
Product name: GOT1inhibitor2c
Packaging: 5mg
Price: $110
Updated: 2021/12/16

CSNpharm

Product number: CSN27598
Product name: GOT1inhibitor2c
Packaging: 10mg
Price: $180
Updated: 2021/12/16

CSNpharm

Product number: CSN27598
Product name: GOT1inhibitor2c
Packaging: 25mg
Price: $300
Updated: 2021/12/16

DC Chemicals

Product number: DC12542
Product name: GOT1inhibitor2c
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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GOT1 inhibitor 2c Chemical Properties,Usage,Production

Uses

GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1].

References

[1] Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678 DOI:10.1016/j.bmcl.2018.04.061
[2] Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17(1):111. DOI:10.1186/s12964-019-0425-4

GOT1 inhibitor 2c Preparation Products And Raw materials

Raw materials

Preparation Products

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GOT1 inhibitor 2c Suppliers

China 32 United States 5 Global 37

Shanghai Lollane Biological Technology Co.,Ltd.

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732973-87-4, GOT1 inhibitor 2cRelated Search:

GOT1 inhibitor 2c

GOT1 inhibitor-1

N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide

GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1

1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)-

GOT1 inhibitor-1, 10 mM in DMSO

732973-87-4