ChemicalBook > CAS DataBase List > L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

Product Name
L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
CAS No.
207278-87-3
Chemical Name
L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
Synonyms
L-THREO-PPMP;L-threo-PPMP, Glucosylceramide synthase inhibitor;L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL;Hexadecanamide, N-[(1S,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-
CBNumber
CB5806094
Molecular Formula
C29H50N2O3
Formula Weight
474.72
MOL File
207278-87-3.mol
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L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Property

Boiling point:
642.8±55.0 °C(Predicted)
Density 
1.005±0.06 g/cm3(Predicted)
pka
13.60±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties,Usage,Production

Uses

L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].

Definition

ChEBI: (1S,2S)-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol is an N-[1-hydroxy-3-(morpholin-4-yl)-1-phenylpropan-2-yl]hexadecanamide in which both stereocentres have S configuration. It is an enantiomer of a (1R,2R)-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.

References

[1] Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20(3):157-68. DOI:10.1023/B:GLYC.0000024254.64450.8b

L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Suppliers

China 4 United States 3 Global 7
TargetMol Chemicals Inc.
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SHANGHAI ZZBIO CO., LTD.
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Aladdin Scientific
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Guangdong Liusheng Trading Co., Ltd.
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207278-87-3, L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCLRelated Search:


  • L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
  • L-THREO-PPMP
  • Hexadecanamide, N-[(1S,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-
  • L-threo-PPMP, Glucosylceramide synthase inhibitor
  • 207278-87-3