1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE
- Product Name
- 1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE
- Chemical Name
- 1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE
- Synonyms
- AKT-I-1/2;AKT INHIBITOR VIII;AKT1/2 KINASE INHIBITOR;AKTI-1/2 TRIFLUOROACETATE SALT HYDRATE;AKT INHIBITOR VIII TRIFLUOROACETATE SALT HYDRATE;1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE;Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one
- CBNumber
- CB5806630
- Molecular Formula
- C36H32F3N7O4
- Formula Weight
- 683.6789896
- MOL File
- Mol file
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Property
- Melting point:
- >255oC (dec.)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly)
- form
- powder
- color
- yellow
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A6730
- Product name
- Akt1/2 kinase inhibitor
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- A6730
- Product name
- Akt1/2 kinase inhibitor
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $1070
- Updated
- 2024/03/01
- Product number
- 5773
- Product name
- Akti-1/2
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $724
- Updated
- 2021/12/16
- Product number
- A1123
- Product name
- Akti-1/2
- Packaging
- 2mg
- Price
- $460
- Updated
- 2021/12/16
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Chemical Properties,Usage,Production
Uses
Akt plays a role in signal transduction pathways of cell proliferation, apoptosis, angiogenesis, and diabetes. Akt1 and Akt2 dual kinase inhibitors are capable of sensitizing tumor cells to certain apoptotic stimuli, and inhibit Akt phosphorylation in vivo. Akt1 kinase activity and its regulation by extracellular signaling factors in vivo in hematopoietic cells suggests the activation of AKT1 involves intracellular translocation of the kinase from cytosol to membrane.
Biochem/physiol Actions
Isozyme selective Akt1/2 kinase inhibitor. In in vitro kinase assays, Akt1/2 kinase inhibitor shows IC50 = 58 nM, 210 nM, and 2.12 mM for Akt1, Akt2, and Akt3, respectively, The inhibition appears to be pleckstrin homology (PH) domain-dependent and the Akt1/2 kinase inhibitor has no inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 μM.
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
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- 51456
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- 80
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- 021-61998551 13122364865
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- Country
- China
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- 9772
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- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
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- 58
- Tel
- 18601717983
- guojing@bioleaper.com
- Country
- China
- ProdList
- 5616
- Advantage
- 58
- Tel
- --
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- sales@advtechind.com
- Country
- United States
- ProdList
- 6075
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