3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione
- Product Name
- 3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione
- CAS No.
- 1360105-53-8
- Chemical Name
- 3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione
- Synonyms
- 3-tert-butyl-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione;3-(1,1-DIMETHYLETHYL)-6-(ETHYLTHIO)-1,3,5-TRIAZINE-2,4(1H,3H)-DIONE;6-(ethylthio)-3-t-butyl-1,3,5-triazine-2,4(1H,3H)-dion;3-TERT-BUTYL-6-ETHYLSULFANYL-1H-1,3,5-TRIAZINE-2,4-DIONE;1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6;3-Sanchoyl-6-(sulfide)-1,3,5-Sanji - 2,4 (1H, 3H) - Niket;3-(tert-Butyl)-6-(sulfanyl)-1,3,5-triazine-2,4(1H,3H)-dione;3-tert-butyl-6-(Ethylthio)-1,3,5-Triazine-2,4(1H,3H)-diketone;1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6-(ethylthio)-
- CBNumber
- CB58093139
- Molecular Formula
- C9H15N3O2S
- Formula Weight
- 229.3
- MOL File
- 1360105-53-8.mol
3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione Property
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 5.15±0.70(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H15N3O2S/c1-5-15-6-10-7(13)12(8(14)11-6)9(2,3)4/h5H2,1-4H3,(H,10,11,13,14)
- InChIKey
- BDGLMLJBANMNCP-UHFFFAOYSA-N
- SMILES
- N1C(SCC)=NC(=O)N(C(C)(C)C)C1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Uses
3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione is used as Ensitrelvir intermediates.
Acquired resistance
T-Butyl isocyanate (1.2 mL, 10.5 mmol) and DBU (1.9 mL, 12.8 mmol) were added to mixture of S-ethylthiourea hydrobromate (1.85 g, 10 mmol) and DMF (9.3 mL) under ice-cooling, and the resulting mixture was stirred for 6 hours. 1,1′-Carbonyldiimidazole (1.95 g, 12 mmol) and DBU (1.9 mL, 12.8 mmol) were added to the reaction mixture under ice-cooling, and the mixture was stirred for 2 hours. 2 mol/L Hydrochloric acid (80 mL) was added to the reaction mixture under ice-cooling over 50 minutes, and the generated powder was collected by filtration. The powder was dissolved in ethyl acetate, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione (1.15 g, yield: 50%) as pale brown powder.
Synthesis
T-Butyl isocyanate (1.2 mL, 10.5 mmol) and DBU (1.9 mL, 12.8 mmol) were added to mixture of S-ethylthiourea hydrobromate (1.85 g, 10 mmol) and DMF (9.3 mL) under ice-cooling, and the resulting mixture was stirred for 6 hours. 1,1′-Carbonyldiimidazole (1.95 g, 12 mmol) and DBU (1.9 mL, 12.8 mmol) were added to the reaction mixture under ice-cooling, and the mixture was stirred for 2 hours. 2 mol/L Hydrochloric acid (80 mL) was added to the reaction mixture under ice-cooling over 50 minutes, and the generated powder was collected by filtration. The powder was dissolved in ethyl acetate, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione (1.15 g, yield: 50%) as pale brown powder.
3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione Suppliers
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 010-68862197 15810698817
- Fax
- 83682022
- huikangqc@126.com
- Country
- China
- ProdList
- 13
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 0531-0531-58897003 15550412551
- Fax
- 0531-58897003
- market@jnchsd.com
- Country
- China
- ProdList
- 230
- Advantage
- 62
- Tel
- 177-6725-7858 15967138206
- Fax
- 0571-85022751
- sales@hzbrown.com
- Country
- China
- ProdList
- 75
- Advantage
- 62
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
- ProdList
- 474
- Advantage
- 55
- Tel
- 029-68669089-8816
- Fax
- +86-29-68669073
- market@xarlm.com
- Country
- China
- ProdList
- 499
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 021-68187180 13681683526
- Fax
- 021-68187179
- lchen@syncozymes.com
- Country
- China
- ProdList
- 317
- Advantage
- 55
- Tel
- 15928766785 15928766785
- Fax
- QQ961458712
- wupengcheng@astatech.cn
- Country
- China
- ProdList
- 1987
- Advantage
- 55
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3506
- Advantage
- 58
- Tel
- 0531-88803958 18866891188
- Fax
- 0531-82777287
- 18853169188@163.com
- Country
- China
- ProdList
- 193
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 18112588827
- sales4@sepharm.com.cn
- Country
- China
- ProdList
- 285
- Advantage
- 60
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 6295
- Advantage
- 60
- Tel
- 0531-68652053 15863796298;
- 2310993908@qq.com
- Country
- China
- ProdList
- 2437
- Advantage
- 58
- Tel
- 0943-6900332 17789447501
- Fax
- 0931-8238232
- zhuanxiajiang@haotianpharm.com
- Country
- China
- ProdList
- 192
- Advantage
- 55
- Tel
- 021-50498136 13564881053
- Fax
- 021-50498136
- products@tbbmed.com
- Country
- China
- ProdList
- 184
- Advantage
- 55
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9288
- Advantage
- 55
- Tel
- 021-31761238 13167072949
- Fax
- 021-31761238
- 3146446224@qq.com
- Country
- China
- ProdList
- 1379
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 10410
- Advantage
- 58
- Tel
- 0571-86828652 18857119830
- Fax
- 0571-83522824
- sales@chemtrue-bio.com
- Country
- China
- ProdList
- 252
- Advantage
- 58
- Tel
- 531-58897070 15254140813
- Fax
- 0531-58897046
- market@jnchsd.com
- Country
- China
- ProdList
- 236
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9985
- Advantage
- 58
- Tel
- 025-58231105-8151
- Fax
- 025-83172562
- marketing@zenjipharma.com
- Country
- China
- ProdList
- 420
- Advantage
- 58
- Tel
- 021-68900963 15618693615
- Fax
- 021-68900963
- sales@jinghaopharma.com
- Country
- China
- ProdList
- 300
- Advantage
- 58
- Tel
- 027-63496417 13007129042
- Fax
- 13476107660
- 3294393103@qq.com
- Country
- China
- ProdList
- 294
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 10267
- Advantage
- 58
- Tel
- 053167801621 15665775653
- Fax
- 053167801621
- sales@guodingpharma.com
- Country
- China
- ProdList
- 491
- Advantage
- 58
- Tel
- +86-18665676617
- Fax
- 18665676617
- Country
- China
- ProdList
- 957
- Advantage
- 58
- Tel
- 0931-4190454 13893344397
- sales@kyxpharma.com
- Country
- China
- ProdList
- 3151
- Advantage
- 58
- Tel
- 18028661570
- 2412659056@qq.com
- Country
- China
- ProdList
- 291
- Advantage
- 58
- Tel
- 0531-88987162 18615427082
- 2823799053@qq.com
- Country
- China
- ProdList
- 544
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 19930505208
- 515253120@qq.com
- Country
- China
- ProdList
- 472
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 021-021-13773155751 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 10524
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 15317222985
- Fax
- binbin.lin@cepharm.cn
- bingna.wang@cepharm.cn
- Country
- China
- ProdList
- 154
- Advantage
- 58
- Tel
- 027-59207796 13429867250
- Fax
- 027-59207796
- w13429867250@163.com
- Country
- China
- ProdList
- 1995
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- 0571-86297909 15268405618
- sisi.xiang@sinopep.com
- Country
- China
- ProdList
- 86
- Advantage
- 58
- Tel
- 793-5181188 18170363299
- yangyuening@jxjfpharma.com
- Country
- China
- ProdList
- 62
- Advantage
- 58
View Lastest Price from 3-(tert-Butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione manufacturers
- Product
- 1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6-(ethylthio)- 1360105-53-8
- Price
- US $9.90-9.90/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2023-03-30
- Product
- 1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6-(ethylthio)- 1360105-53-8
- Price
- US $9.90-9.90/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2023-03-30
- Product
- 1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6-(ethylthio)- 1360105-53-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2023-11-02