ChemicalBook > CAS DataBase List > 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-

4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-

Product Name: 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
CAS No.: 1226443-41-9
Chemical Name: 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
Synonyms: HQ461;HQ461, 10 mM in DMSO;4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-;2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide;N-(5-methyl-1,3-thiazol-2-yl)-2-{2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl}acetamide;cyclin K degrader,Cyclin dependent kinase,molecular glue,HQ461,HQ 461,HQ-461,CDK12 substrate phosphorylation,inhibit,CDK,Inhibitor,Molecular Glues,DNA damage
CBNumber: CB58119666
Molecular Formula: C15H15N5OS2
Formula Weight: 345.44
MOL File: 1226443-41-9.mol

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4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Property

Density: 1.436±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 8.11±0.50(Predicted)
color: Gray to light brown
InChI: InChI=1S/C15H15N5OS2/c1-9-4-3-5-12(17-9)19-15-18-11(8-22-15)6-13(21)20-14-16-7-10(2)23-14/h3-5,7-8H,6H2,1-2H3,(H,16,20,21)(H,17,18,19)
InChIKey: QMRBCNQCRMTXBE-UHFFFAOYSA-N
SMILES: S1C=C(CC(NC2=NC=C(C)S2)=O)N=C1NC1=NC(C)=CC=C1

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Hazard and Precautionary Statements (GHS)

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4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Chemical Properties,Usage,Production

Uses

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].

References

[1] Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994. DOI:10.7554/eLife.59994

4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1226443-41-9, 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-Related Search:

4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-

HQ461

cyclin K degrader,Cyclin dependent kinase,molecular glue,HQ461,HQ 461,HQ-461,CDK12 substrate phosphorylation,inhibit,CDK,Inhibitor,Molecular Glues,DNA damage

2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide

N-(5-methyl-1,3-thiazol-2-yl)-2-{2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl}acetamide

HQ461, 10 mM in DMSO

1226443-41-9