ChemicalBook > CAS DataBase List > 1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-

1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-

Product Name
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
CAS No.
1623416-31-8
Chemical Name
1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
Synonyms
AG-636;AG-636, 10 mM in DMSO;1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-;1-Methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid;inhibit,oral,AG 636,AG-636,reversible,DHODH,anticancer,AG636,Inhibitor,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
CBNumber
CB58145445
Molecular Formula
C21H17N3O2
Formula Weight
343.38
MOL File
1623416-31-8.mol
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1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Property

Boiling point:
619.3±43.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 31.25 mg/mL (91.01 mM; Need ultrasonic)
form 
A solid
pka
2.73±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0138680
Product name
AG-636
Purity
98.02%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0138680
Product name
AG-636
Purity
98.02%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0138680
Product name
AG-636
Purity
98.02%
Packaging
25mg
Price
$1300
Updated
2021/12/16
ChemScene
Product number
CS-0138680
Product name
AG-636
Purity
98.02%
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0138680
Product name
AG-636
Purity
98.02%
Packaging
100mg
Price
$3400
Updated
2021/12/16
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1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Chemical Properties,Usage,Production

Uses

AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects[1].

in vivo

AG-636 (10-100 mg/kg ; oral gavage; twice daily; for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model[1].

Animal Model:Transgenic female 6-8-week-old CB17/Icr-Prkdcscid/IcrIcoCrl (CB17 SCID) mice injected with OCILY19 cells[1]
Dosage:10 mg/kg, 30 mg/kg, or 100 mg/kg
Administration:Oral gavage; twice daily; for 14 days
Result:Resulted in robust tumor growth inhibition in xenograft lymphoma tumor models.

References

[1] Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515. DOI:10.1158/1535-7163.MCT-20-0550

1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)- Suppliers

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1623416-31-8, 1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-Related Search:


  • 1H-Benzotriazole-7-carboxylic acid, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-
  • AG-636
  • 1-Methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid
  • inhibit,oral,AG 636,AG-636,reversible,DHODH,anticancer,AG636,Inhibitor,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
  • AG-636, 10 mM in DMSO
  • 1623416-31-8