6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
- Product Name
- 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
- CAS No.
- 135900-33-3
- Chemical Name
- 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
- Synonyms
- 6-TRIFLUOROMETHOXY-PYRIDIN-3-Y;6-(Trifluoromethoxy)3-pyridinamine;6-(trifluoroMethoxy)pyridin-3-aMine;3-Amino-6-(trifluoromethoxy)pyridine;5-Amino-2-(trifluoromethoxy)pyridine;6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE;3-PyridinaMine, 6-(trifluoroMethoxy)-;3-Amino-6-(trifluoromethoxy)pyridine 95%;6-(trifluoromethoxy)pyridin-3-amine hydrochloride
- CBNumber
- CB5819533
- Molecular Formula
- C6H5F3N2O
- Formula Weight
- 178.11
- MOL File
- 135900-33-3.mol
6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE Property
- Melting point:
- 31-33 °C(Solv: cyclohexane (110-82-7))
- Boiling point:
- 203.3±35.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.72±0.10(Predicted)
- Appearance
- Colorless to light pink <31°C Solid,>33°C Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T897680
- Product name
- 6-(Trifluoromethoxy)pyridin-3-amine
- Packaging
- 2.5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- T897680
- Product name
- 6-(Trifluoromethoxy)pyridin-3-amine
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- HCH0353652
- Product name
- 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.83
- Updated
- 2021/12/16
- Product number
- PC53248
- Product name
- 3-Amino-6-(trifluoromethoxy)pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 4H56-3-AH
- Product name
- 6-(Trifluoromethoxy)pyridin-3-amine
- Packaging
- 250mg
- Price
- $1120
- Updated
- 2021/12/16
6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE Chemical Properties,Usage,Production
Uses
6-(Trifluoromethoxy)pyridin-3-amine can be used to study synthesis of (Trifluoromethoxy)pyridines.
Synthesis
1221172-05-9
135900-33-3
General procedure for the synthesis of 6-(trifluoromethoxy)pyridin-3-amine from compound (CAS:1221172-05-9): compound 81 (2.00 g, 9.43 mmol, 1.0 eq.), 10% Pd/C (1.0 g), and ammonium formate (1.2 g, 18.9 mmol, 2.0 eq.) were dissolved in methanol (20 mL) and heated to 55 °C for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filtrate was concentrated to obtain the crude product. The crude product was partitioned between ethyl acetate (100 mL) and 4% NaOH aqueous solution (30 mL) to separate the organic layer. The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to give the target product 82 (1.50 g, 8.38 mmol, 89.4% yield) as a yellow oil.
References
[1] Patent: WO2016/144792, 2016, A1. Location in patent: Paragraph 00537
[2] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 49
[3] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066