1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

Product Name: 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-
CAS No.: 2377858-38-1
Chemical Name: 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-
Synonyms: SCR130;SCR130, 10 mM in DMSO;2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4,5]dec-1-ene-6,10-dione;1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-;DNA/RNA Synthesis,NHEJ,Inhibitor,SCR130,Apoptosis,Ligase-IV,DNA,anticancer,p-p53,SCR 130,cytotoxicity,inhibit,SCR-130
CBNumber: CB58204430
Molecular Formula: C19H13Cl2N3O2S
Formula Weight: 418.3
MOL File: 2377858-38-1.mol

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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Property

Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: sonicated),: DMSO
form: Solid
pka: 7.30±0.60(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Chemical Properties,Usage,Production

Uses

SCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor. SCR130 inhibits the end-joining of DNA in a Ligase IV-dependent manner. SCR130 is specific to Ligase IV, and shows minimal or no effect on Ligase III and Ligase I mediated joining. SCR130 induces cell apoptosis and has anticancer activity[1].

References

[1] Ujjayinee Ray, et al. Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics. Mol Carcinog. 2020 Jun;59(6):618-628. DOI:10.1002/mc.23186

1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- Suppliers

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2377858-38-1, 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-Related Search:

1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

SCR130

DNA/RNA Synthesis,NHEJ,Inhibitor,SCR130,Apoptosis,Ligase-IV,DNA,anticancer,p-p53,SCR 130,cytotoxicity,inhibit,SCR-130

2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4,5]dec-1-ene-6,10-dione

SCR130, 10 mM in DMSO

2377858-38-1