Polymyxin B nonapeptide TFA

Product Name: Polymyxin B nonapeptide TFA
CAS No.: 2220175-42-6
Chemical Name: Polymyxin B nonapeptide TFA
Synonyms: Polymyxin B nonapeptide TFA;(2S,3R)-2-Amino-N-((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide 2,2,2-trifluoroacetate
CBNumber: CB58205871
Molecular Formula: C45H75F3N14O13
Formula Weight: 1077.18
MOL File: 2220175-42-6.mol

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Polymyxin B nonapeptide TFA Property

storage temp.: Store at -20°C,protect from light
form: Solid
color: White to off-white
Water Solubility: Water: 100 mg/mL (65.22 mM)
Sequence: Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0128232
Product name: PolymyxinBnonapeptide(TFA)
Purity: 99.80%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0128232
Product name: PolymyxinBnonapeptide(TFA)
Purity: 99.80%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0128232
Product name: PolymyxinBnonapeptide(TFA)
Purity: 99.80%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0128232
Product name: PolymyxinBnonapeptide(TFA)
Purity: 99.80%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

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Polymyxin B nonapeptide TFA Chemical Properties,Usage,Production

Uses

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3].

in vivo

Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate^[2].

References

[1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374

Polymyxin B nonapeptide TFA Preparation Products And Raw materials

Raw materials

Preparation Products

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Polymyxin B nonapeptide TFA Suppliers

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2220175-42-6, Polymyxin B nonapeptide TFARelated Search:

POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE

Polymyxin B nonapeptide TFA

(2S,3R)-2-Amino-N-((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide 2,2,2-trifluoroacetate

2220175-42-6