Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-

Product Name: Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
CAS No.: 2451481-08-4
Chemical Name: Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
Synonyms: sulfopin;1-dioxido-3-thienyl)-;sulfopin, 10 mM in DMSO;2-dimethylpropyl)-N-(tetrahydro-1;2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide;Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-;neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293
CBNumber: CB58215081
Molecular Formula: C11H20ClNO3S
Formula Weight: 281.8
MOL File: 2451481-08-4.mol

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Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Property

Boiling point:: 455.5±45.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: -1.36±0.20(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

DC Chemicals

Product number: 028490
Product name: Sulfopin
Packaging: 001
Price: $350
Updated: 2021/12/16

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Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Chemical Properties,Usage,Production

Description

Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish.

References

Dubiella et al. (2021), Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo; Nat. Cham. Biol. 17 954

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Suppliers

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2451481-08-4, Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-Related Search:

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Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-

sulfopin

1-dioxido-3-thienyl)-

2-dimethylpropyl)-N-(tetrahydro-1

neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293

2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide

sulfopin, 10 mM in DMSO

2451481-08-4

C11H20ClNO3S