ChemicalBook > CAS DataBase List > A 71623

A 71623

Product Name
A 71623
CAS No.
130408-77-4
Chemical Name
A 71623
Synonyms
A 71623;A-71623 TFA;N-Boc-L-Trp-[(2S)-2-Amino*-6-[3-(2-methylphenyl)ureido]hexanoyl]-L-Asp-N-methyl-L-Phe-NH2;N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide;L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-;N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-TRYPTOPHYL-N6-[[(2-METHYLPHENYL)AMINO]CARBONYL]-L-LYSYL-L-ALPHA-ASPARTYL-NA-METHYL-L-PHENYLALANINAMIDE
CBNumber
CB5829349
Molecular Formula
C44H56N8O9
Formula Weight
840.96
MOL File
130408-77-4.mol
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A 71623 Property

storage temp. 
Desiccate at -20°C
solubility 
Soluble to 1 mg/ml in 20mM PBS buffer
form 
solid
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2411
Product name
A-71623
Packaging
1
Price
$306
Updated
2021/12/16
TRC
Product number
A965340
Product name
A-71623
Packaging
1mg
Price
$215
Updated
2021/12/16
Usbiological
Product number
254494
Product name
A-71623
Packaging
1mg
Price
$573
Updated
2021/12/16
ApexBio Technology
Product number
B7046
Product name
A-71623
Packaging
1mg
Price
$448
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000407
Product name
A-71623
Purity
95.00%
Packaging
1MG
Price
$782.23
Updated
2021/12/16
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A 71623 Chemical Properties,Usage,Production

Uses

A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor.

Biological Activity

Potent CCK 1 agonist (IC 50 = 3.7 nM) with 1200-fold selectivity over the CCK 2 receptor. Suppresses food intake following central or peripheral administration.

in vivo

A71623 (A-63387; i.c.v., but not i.p., injections) reduces food intakes and suppresses intakes of a liquid diet in both deprived and sated rats[2].
A71623 dampens Purkinje neuron pathology and associates deficits in motor performance in Pcp2-ATXN1[30Q]D776;Cck-/- and Pcp2-AXTN1[82Q] mice[3].
A71623 improves motor performance of Pcp2-ATXN2[127Q] SCA2 mice[3].

Animal Model:Adult male, Sprague-Dawley rats[2]
Dosage:5 μL
Administration:Intracerebroventricular (i.c.v) administration, A-71623 was infused using a 28 gauge injection cannula in a volume of 5uL over 60 s
Result:Reduced food intakes and suppressed intakes of a liquid diet.
Animal Model:ATXN1[30Q]-D776, ATXN1[82Q]-D776, ATXN2[127Q], and WT/FVB/NJ mice [3]
Dosage:0.02 mg/kg/day
Administration:Osmotic minipumps containing either A71623 (0.02mg/kg/day) were implanted intraperitoneally (i.p.)
Result:Treatment dampened Purkinje neuron pathology in ATXN1[30Q]D776;Cck-/- mice and ATXN1[82Q] mice.
Improved motor performance in ATXN2[127Q] mice.

IC 50

CCKAR

storage

Store at -20°C

References

[1]. gracey dj, bell r, king dj. differential effects of the ccka receptor ligands pd-140,548 and a-71623 on latent inhibition in the rat. progress in neuro-psychopharmacology and biological psychiatry, 2002, 26(3): 497-504.
[2]. lin cw, shiosaki k, miller tr, et al. characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, a-71623 and a-70874, that exhibit high potency and selectivity for cholecystokinin-a receptors. molecular pharmacology, 1991, 39(3): 346-351.
[3]. kaufmann r, lindschau c, scho t, et al. type b cholecystokinin receptors on rat glioma c6 cells. binding studies and measurement of intracellular calcium mobilization. brain research, 1994, 639(1): 109-114.

A 71623 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 71623 Suppliers

China 21 Europe 1 Germany 3 United Kingdom 1 United States 3 USA 1 Global 30
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
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China
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Hangzhou Peptidego Biotech Co.,Ltd.
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0571-87213919
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Eric@peptidego.com
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China
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7408
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Zhejiang J&C Biological Technology Co.,Limited
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+1-2135480471
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sales@sarms4muscle.com
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China
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Wuxi Helen Biotechnology Co., Ltd.,
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0510-85629785 18013409632
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0510-85625359
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sales@reading-chemicals.com
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China
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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China
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44894
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Shanghai Universal Biotech Co.,Ltd
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15921930842 15921930842
Email
yh-wang@univ-bio.com
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China
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25004
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Shaoxing Junyu Biotechnology Co., LTD
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0571-0571-88211921 19105816207
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sales4@gotopbio.com
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China
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Hangzhou Sinoda Pharmaceutical Technology Co. LTD
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0571-87213919 17306812703
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3007955328@qq.com
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China
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Shanghai HongTide Biotechnology Co.,Ltd.
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15318089928
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alex@hanhonggroup.com
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China
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130408-77-4, A 71623Related Search:

BOC-TRP-NHME Boc-L-Tryptophan amide A 71623

  • N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-TRYPTOPHYL-N6-[[(2-METHYLPHENYL)AMINO]CARBONYL]-L-LYSYL-L-ALPHA-ASPARTYL-NA-METHYL-L-PHENYLALANINAMIDE
  • N-Boc-L-Trp-[(2S)-2-Amino*-6-[3-(2-methylphenyl)ureido]hexanoyl]-L-Asp-N-methyl-L-Phe-NH2
  • N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide
  • A 71623
  • L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-
  • A-71623 TFA
  • 130408-77-4
  • C44H56N8O9