ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE
- Product Name
- ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE
- CAS No.
- 7126-50-3
- Chemical Name
- ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE
- Synonyms
- ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE;1H-Pyrrole-2-carboxylic acid, 5-forMyl-, ethyl ester
- CBNumber
- CB5832020
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 7126-50-3.mol
ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE Property
- Melting point:
- 72.5-73.5 °C
- Boiling point:
- 82-86 °C(Press: 0.05 Torr)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.45±0.50(Predicted)
- Appearance
- Yellow to orange Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E703008
- Product name
- Ethyl5-formyl-1H-pyrrole-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B874
- Product name
- Ethyl5-formyl-1H-pyrrole-2-carboxylate
- Packaging
- 250mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 073517
- Product name
- Ethyl 5-formyl-1H-pyrrole-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- OR912411
- Product name
- Ethyl5-formyl-1H-pyrrole-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 073517
- Product name
- Ethyl 5-formyl-1H-pyrrole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
2199-43-1
68-12-2
7126-50-3
7126-57-0
A-6 Synthesis of ethyl 5-formyl-1H-pyrrole-2-carboxylate and ethyl 4-formyl-1H-pyrrole-2-carboxylate Procedure: 75 mL of dichloromethane solution of phosphorus trichloride (25 mL, 0.27 mol) was slowly added to 75 mL of dichloroethane solution of N,N-dimethylformamide (21 mL, 0.27 mol) at 0 °C. The reaction mixture was stirred at room temperature for 30 minutes and then cooled to 0°C again. Subsequently, a solution of ethyl pyrrole-2-carboxylate (25 g, 0.18 mol) dissolved in 50 mL of dichloroethane was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 30 minutes and then continued stirring at 40 °C for 1 hour. After completion of the reaction, the mixture was carefully poured into ice water and the pH was adjusted to 11 with 5N sodium hydroxide solution.The reaction mixture was extracted with ethyl acetate, the organic phases were combined, washed sequentially with water and saturated saline, and finally dried with anhydrous sodium sulfate. Separation by column chromatography (eluent ratio 1:3 ethyl acetate:hexane) gave 15 g (50% yield) of ethyl 5-formyl-1H-pyrrole-2-carboxylate and 2 g (7% yield) of ethyl 4-formyl-1H-pyrrole-2-carboxylate. The products were confirmed by 1H-NMR (300 MHz, dimethylsulfoxide-d6) and mass spectrometry: 1H-NMR δ 13.02 (br s, 1H, NH), 9.69 (s, 1H, CHO), 6.95 (d, 1H), 6.86 (d, 1H), 4.27 (q, 2H, CH2), 1.28 (t, 3H, CH3). ms m/z 167 [M+].
References
[1] Journal of Organic Chemistry, 1993, vol. 58, # 25, p. 7245 - 7257
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6911 - 6923
[3] Patent: US2004/204407, 2004, A1. Location in patent: Page/Page column 16
[4] Patent: US2004/204407, 2004, A1. Location in patent: Page/Page column 21
[5] Patent: US2004/266843, 2004, A1. Location in patent: Page 12
ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE manufacturers
- Product
- ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE 7126-50-3
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg, 50kg
- Release date
- 2020-01-09