ChemicalBook > CAS DataBase List > 3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-

3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-

Product Name
3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-
CAS No.
1619931-27-9
Chemical Name
3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-
Synonyms
GB002;PK-10571;Seralutinib;Valine Impurity 98;Seralutinib (GB002);Seralutinib (PK-10571;Seralutinib, 10 mM in DMSO;(S)-N-(3-(1-((6-(3,4-Dimethoxyphenyl)pyrazin-2-yl)amino)ethyl)phenyl)-5-methylnicotinamide;N-3-(1S)-1-6-(3,4-Dimethoxy-phenyl)-pyrazin-2-ylamino-ethylphenyl-5-methylpyridin-3-carboxamide;3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-
CBNumber
CB58352036
Molecular Formula
C27H27N5O3
Formula Weight
469.54
MOL File
1619931-27-9.mol
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3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- Property

Boiling point:
601.4±55.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (212.98 mM; Need ultrasonic)
form 
Solid
pka
12.16±0.70(Predicted)
color 
White to light yellow
InChIKey
JHJNPOSPVGRIAN-SFHVURJKSA-N
SMILES
C1=NC=C(C)C=C1C(NC1=CC=CC([C@@H](NC2=NC(C3=CC=C(OC)C(OC)=C3)=CN=C2)C)=C1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0116463
Product name
Seralutinib
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0116463
Product name
Seralutinib
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0116463
Product name
Seralutinib
Packaging
25mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0116463
Product name
Seralutinib
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0116463
Product name
Seralutinib
Packaging
100mg
Price
$3400
Updated
2021/12/16
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3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- Chemical Properties,Usage,Production

Uses

Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC50s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension[1][2].

in vivo

Seralutinib (GB002) (two-week treatment, delivered by inhalation) significantly reduces right ventricular systolic pressure and mean pulmonary artery pressure. Hemodynamic changes are accompanied by reduced pulmonary arteriole muscularization and restoration of BMPR2 protein expression in the lung lobes in Seralutinib (GB002)-treated animals. Seralutinib (GB002) is well tolerated[1].
Seralutinib-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation[2].
Seralutinib dose- and time-dependently induces lung BMPR2 protein expression[2].

IC 50

PDGFRα; PDGFRβ; CSF1R: 8 nM (IC50); c-KIT: 14 nM (IC50)

References

[1] Robert P. Frantz1, et.al. Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Inhaled GB002 (Seralutinib) for the Treatment of World Health Organization Group 1 Pulmonary Arterial Hypertension
[2] Anna Galkin, et al. Abstract 11102: Gb002, A Novel Inhaled Pdgfr Kinase Inhibitor, Demonstrates Efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah). Circulation. 2019;140:A11102.
[3] Anna Galkin, et al. Pharmacologic Characterization of GB002, a Novel Inhaled PDGFR Kinase Inhibitor in Development for Pulmonary Arterial Hypertension (PAH).

3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- Suppliers

China 48 United States 2 Global 50
Taizhou Nanfeng Pharmaceutical Research Institute
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nanfengdrug@163.com; 18616377689
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nanfengdrug@163.com
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China
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20009
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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17702719238 18971495150;
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sales@sun-shinechem.com
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China
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ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878
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0086-0757-85406358
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chemcell@hotmail.com
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China
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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sales-cpd@caerulumpharma.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
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China
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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2989
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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View Lastest Price from 3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- manufacturers

Henan Fengda Chemical Co., Ltd
Product
3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl- 1619931-27-9
Price
US $8.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

1619931-27-9, 3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-Related Search:


  • 3-Pyridinecarboxamide, N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)-2-pyrazinyl]amino]ethyl]phenyl]-5-methyl-
  • Seralutinib
  • PK-10571
  • GB002
  • Seralutinib (GB002)
  • Seralutinib (PK-10571
  • (S)-N-(3-(1-((6-(3,4-Dimethoxyphenyl)pyrazin-2-yl)amino)ethyl)phenyl)-5-methylnicotinamide
  • PK 10571,Seralutinib,inhibit,arterial,PDGFR,PK10571,PK-10571,PAH,Pulmonary,hypertension,GB 002,GB-002,Inhibitor,Platelet-derived growth factor receptor
  • N-3-(1S)-1-6-(3,4-Dimethoxy-phenyl)-pyrazin-2-ylamino-ethylphenyl-5-methylpyridin-3-carboxamide
  • Valine Impurity 98
  • Seralutinib, 10 mM in DMSO
  • 1619931-27-9