CCT 018159

Product Name: CCT 018159
CAS No.: 171009-07-7
Chemical Name: CCT 018159
Synonyms: CCT 018159;HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem;4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol;1,3-Benzenediol, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-
CBNumber: CB5837186
Molecular Formula: C20H20N2O4
Formula Weight: 352.38
MOL File: 171009-07-7.mol

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CCT 018159 Property

Boiling point:: 547.3±50.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka: 8.84±0.48(Predicted)
form: White solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 385920
Product name: HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem<br />The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 10012591
Product name: CCT018159
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 10012591
Product name: CCT018159
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 10012591
Product name: CCT018159
Purity: ≥98%
Packaging: 10mg
Price: $156
Updated: 2024/03/01

Cayman Chemical

Product number: 10012591
Product name: CCT018159
Purity: ≥98%
Packaging: 50mg
Price: $492
Updated: 2022/04/27

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CCT 018159 Chemical Properties,Usage,Production

Uses

CCT 018159 is a cell-permeable compound that inhibits Hsp90 ATPase.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole carrying 1,4-benzodioxane-6-yl and 5-ethyl-2,4-dihydroxyphenyl substituents at positions 4 and 5 respectively.

Biological Activity

Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC 50 = 5.7 μ M) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

in vitro

cct018159 was identified by high-throughput screening inhibiting human hsp90beta with comparable potency to 17-aag and with similar atp-competitive kinetics. x-ray crystallographic structures of the yeast hsp90 complexed with cct018159 showed binding properties similar to radicicol. the mean cellular gi50 of cct018159 across a panel of human cancer cell lines, including melanoma, was 5.3 μm. unlike 17-aag, the in-vitro antitumor activity of cct018159 was independent of nqo1/dt-diaphorase and p-glycoprotein expression. the signature of hsp90 inhibition, comprising increased expression of hsp72 protein and depletion of erbb2, cdk4, c-raf, and mutant b-raf, was indicated in human cancer cell lines treated with cct018159 [1].

in vivo

in human tumor xenografts including skmel 28 melanoma cells, cct018159 was found to induce the expression of hsp72 as well as erbb2, cdk4 and dc-raf [1].

IC 50

3.2 and 6.6 μm for human hsp90β and yeast hsp90, respectively

storage

Store at +4°C

References

[1] s. y. sharp, k. boxall, m. rowlands, et al. in vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. cancer research 67(5), 2206-2216 (2007).

CCT 018159 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT 018159 Suppliers

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171009-07-7, CCT 018159Related Search:

2-(1H-PYRAZOL-3-YL)PHENOL 3-(2-HYDROXY-5-METHYLPHENYL)PYRAZOLE CCT 018159 3-(5-ETHYL-2-HYDROXYPHENYL)PYRAZOLE SALOR-INT L249092-1EA

CCT 018159

4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

1,3-Benzenediol, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-

171009-07-7