BAY 36-7620
- Product Name
- BAY 36-7620
- CAS No.
- 232605-26-4
- Chemical Name
- BAY 36-7620
- Synonyms
- BAY 36-7620;(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one;1H-Cyclopenta[c]furan-1-one, hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-, (3aS,6aS)-;(3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
- CBNumber
- CB5838370
- Molecular Formula
- C19H18O2
- Formula Weight
- 278.35
- MOL File
- 232605-26-4.mol
BAY 36-7620 Property
- Boiling point:
- 471.9±34.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- <27.84mg/ml in ethanol; <27.84mg/ml in DMSO
- form
- solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 2501
- Product name
- Bay36-7620
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $252
- Updated
- 2021/12/16
- Product number
- B119003
- Product name
- Bay36-7620
- Packaging
- 2.5mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- B5309
- Product name
- Bay36-7620
- Packaging
- 10mg
- Price
- $377
- Updated
- 2021/12/16
- Product number
- BIO0000358
- Product name
- BAY 36-7620
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $750.7
- Updated
- 2021/12/16
BAY 36-7620 Chemical Properties,Usage,Production
Uses
Bay 36-7620, is an inhibitor of metabotropic glutamate receptor 1 (mGlu1 receptor), and thus suppresses tumor growth and angiogenesis in experimental non-small cell lung cancer (NSCLC).
Biological Activity
Selective mGlu 1 receptor non-competitive antagonist (IC 50 = 0.16 μ M) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
in vitro
bay36-7620 is a potent and selective antagonist at mglu1receptors and inhibits >60% of mglu1a receptor constitutive activity (ic50 = 0.38 μm). bay36-7620 is thus the first described mglu1 receptor inverse agonist. moreover, bay36-7620 did not displace the [3h]quisqualate binding from the glu-binding pocket, indicating that bay36-7620 is a noncompetitive mglu1 antagonist [2].
in vivo
bay 36-7620 protected against pentylenetetrazole-induced convulsions in the mouse. as assessed in rats, bay 36-7620 was devoid of the typical side effects of the ionotropic glutamate (iglu) receptor antagonists phencyclidine and mk-801. therefore, bay 36-7620 did not disrupt sensorimotor gating, induce phencyclidine-like discriminative effects or stereotypical behavior, or facilitate intracranial self-stimulated behavior [3].
storage
Store at +4°C
References
[1] carroll fy, stolle a, beart pm, voerste a, brabet i, mauler f, joly c, antonicek h, bockaert j, müller t, pin jp, prézeau l. bay36-7620: a potent non-competitive mglu1 receptor antagonist with inverse agonist activity. mol pharmacol. 2001 may;59(5):965-73.
[2] de vry j, horváth e, schreiber r. neuroprotective and behavioral effects of the selective metabotropic glutamate mglu(1) receptor antagonist bay 36-7620. eur j pharmacol. 2001 oct 5;428(2):203-14.
BAY 36-7620 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 36-7620 Suppliers
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